...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Using Domestic and Free-Ranging Arctic Canid Models for Environmental Molecular Toxicology Research
【24h】

Using Domestic and Free-Ranging Arctic Canid Models for Environmental Molecular Toxicology Research

机译：使用国内和免费的北极犬科动物模型进行环境分子毒理学研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The use of sentinel species for population and ecosystem health assessments has been advocated as part of a One Health perspective. The Arctic is experiencing rapid change, including climate and environmental shifts, as well as increased resource development, which will alter exposure of biota to environmental agents of disease. Arctic canid species have wide geographic ranges and feeding ecologies and are often exposed to high concentrations of both terrestrial and marine-based contaminants. The domestic dog (Canis lupus familiaris) has been used in biomedical research for a number of years and has been advocated as a sentinel for human health due to its proximity to humans and, in some instances, similar diet Exploiting the potential of molecular tools for describing the toxicogenomics of Arctic canids is critical for their development as biomedical models as well as environmental sentinels. Here, we present three approaches analyzing toxicogenomics of Arctic contaminants in both domestic and free-ranging canids (Arctic fox, Vulpes lagopus). We describe a number of confounding variables that must be addressed when conducting toxicogenomics studies in canid and other mammalian models. The ability for canids to act as models for Arctic molecular toxicology research is unique and significant for advancing our understanding and expanding the tool box for assessing the changing landscape of environmental agents of disease in the Arctic.
机译：已提倡将前哨物种用于人口和生态系统健康评估，这是“一个健康”观点的一部分。北极正在经历迅速的变化，包括气候和环境的变化，以及资源开发的增加，这将改变生物群系对疾病的环境影响。北极犬科物种的地理范围和摄食生态范围广，并且经常暴露于高浓度的陆地和海洋污染物中。家犬（犬天狼犬）已经在生物医学研究中使用了多年，由于它与人类的亲近性以及在某些情况下的类似饮食而被提倡为人类健康的前哨。挖掘分子工具的潜力描述北极犬的毒理基因组学对于它们作为生物医学模型以及环境标记的发展至关重要。在这里，我们介绍了三种分析家养犬和散养犬（北极狐，狐狸）的北极污染物的毒理基因组学的方法。我们描述了在犬科动物和其他哺乳动物模型中进行毒理基因组学研究时必须解决的许多混杂变量。犬科动物作为北极分子毒理学研究模型的能力是独特的，对于增进我们的理解和扩大评估北极环境病原体格局的工具箱具有重要意义。

著录项

  • 来源
    《Environmental Science & Technology》 |2016年第4期|1990-1999|共10页
  • 作者

    John R. Harley; Theo K. Bammler; Federico M. Farin; Richard P. Beyer; Terrance J. Kavanagh; Kriya L. Dunlap; Katrina K. Knott; Gina M. Ylitalo; Todd M. OHara;

  • 作者单位

    Department of Chemistry and Biochemistry, University of Alaska Fairbanks, 900 Yukon Drive Room 194, Fairbanks, Alaska 99775-6160, United States;

    Center for Ecogenetics and Environmental Health, Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE #100, Seattle, Washington 98105 United States;

    Center for Ecogenetics and Environmental Health, Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE #100, Seattle, Washington 98105 United States;

    Center for Ecogenetics and Environmental Health, Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE #100, Seattle, Washington 98105 United States;

    Center for Ecogenetics and Environmental Health, Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE #100, Seattle, Washington 98105 United States;

    Department of Chemistry and Biochemistry, University of Alaska Fairbanks, 900 Yukon Drive Room 194, Fairbanks, Alaska 99775-6160, United States;

    Memphis Zoo, 2000 Prentiss Place, Memphis, Tennessee 38112, United States;

    Environmental Fisheries and Sciences Division, Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, 2725 Montlake Boulevard E. Seattle, Washington 98112-2013, United States;

    Department of Veterinary Medicine, University of Alaska, Fairbanks, 901 Koyukuk, Fairbanks, Alaska 99775-7750, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号