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首页> 外文期刊>Environmental Science & Technology >Photochemical Transformation of Aminoglycoside Antibiotics in Simulated Natural Waters
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Photochemical Transformation of Aminoglycoside Antibiotics in Simulated Natural Waters

机译：模拟天然水中氨基糖苷类抗生素的光化学转化

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摘要

Aminoglycoside antibiotics are widely used in human therapy and veterinary medicine. We report herein a detailed study on the natural-organic-matter- (N0M-) photosensitized degradation of aminoglycosides in aqueous media under simulated solar irradiation. It appears that the direct reaction of the excited states of NOM (~3NOM~*) with aminoglycosides is minor. The contributions of reactive oxygen species (ROSs) in the bulk solutions are also unimportant, as determined by an assessment based on steady-state concentrations and bimolecular reaction rate constants in a homogeneous reaction model. The inhibition of the photodegradation by isopropamide is rationalized through competitive sorption with aminoglycosides on the NOM surface, whereas the addition of isopropanol negligibly affects degradation because it quenches HO~* in the bulk solution but not HO~* localized on the NOM surface where aminoglycosides reside. Therefore, a sorption-enhanced phototransformation mechanism is proposed. The sorption of aminoglycosides on NOM follows a dual-mode model involving Langmuir and linear isotherms. The steady-state concentration of HO~* on the surface of NOM was calculated as 10~(-14) M, 2 orders of magnitude higher man that in the bulk solution. This fundamental information is important in the assessment of the fate and transport of aminoglycosides in aqueous environments.
机译：氨基糖苷类抗生素广泛用于人体治疗和兽医学。我们在此报告了在模拟太阳辐射下水性介质中氨基糖苷的自然有机物（N0M-）光敏降解的详细研究。似乎NOM（〜3NOM〜*）的激发态与氨基糖苷的直接反应很小。正如在均相反应模型中基于稳态浓度和双分子反应速率常数的评估所确定的那样，本体溶液中活性氧种类（ROSs）的贡献也不重要。异丙酰胺对光降解的抑制作用是通过与NOM表面上的氨基糖苷竞争性吸附来实现的，而异丙醇的加入对降解的影响微不足道，因为它可以使本体溶液中的HO〜*淬灭，而不会破坏位于氨基糖苷所在的NOM表面的HO〜*。 。因此，提出了一种吸附增强的光转化机理。氨基糖苷在NOM上的吸附遵循涉及Langmuir和线性等温线的双模模型。计算得出NOM表面的HO〜*稳态浓度为10〜（-14）M，比本体溶液中的浓度高2个数量级。这些基本信息对于评估水性环境中氨基糖苷的去向和转运非常重要。

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  • 来源
    《Environmental Science & Technology》 |2016年第6期|2921-2930|共10页
  • 作者

    Rui Li; Cen Zhao; Bo Yao; Dan Li; Shuwen Yan; Kevin E. OShea; Weihua Song;

  • 作者单位

    Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China;

    Department of Chemistry & Biochemistry, Florida International University, Miami, Florida 33199, United States;

    Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China;

    Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China;

    Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China;

    Department of Chemistry & Biochemistry, Florida International University, Miami, Florida 33199, United States;

    Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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