...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Human Exposure to Wastewater-Derived Pharmaceuticals in Fresh Produce: A Randomized Controlled Trial Focusing on Carbamazepine
【24h】

Human Exposure to Wastewater-Derived Pharmaceuticals in Fresh Produce: A Randomized Controlled Trial Focusing on Carbamazepine

机译：人类暴露于新鲜农产品中的废水衍生药物：以卡马西平为重点的随机对照试验

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Fresh water scarcity has led to increased use of reclaimed wastewater as an alternative and reliable source for crop irrigation. Beyond microbiological safety, concerns have been raised regarding contamination of reclaimed wastewater by xenobiotics including pharmaceuticals. This study focuses on carbamazepine, an anticonvulsant drug which is ubiquitously detected in reclaimed wastewater, highly persistent in soil, and taken up by crops. In a randomized controlled trial we demonstrate mat healthy individuals consuming reclaimed wastewater-irrigated produce excreted carbamazepine and its metabolites in their urine, while subjects consuming fresh water-irrigated produce excreted undetectable or significantly lower levels of carbamazepine. We also report that the carbamazepine metabolite pattern at this low exposure level differed from that observed at therapeutic doses. This "proof of concept" study demonstrates that human exposure to xenobiotics occurs through ingestion of reclaimed wastewater-irrigated produce, providing real world data which could guide risk assessments and policy designed to ensure the safe use of wastewater for crop irrigation.
机译：淡水短缺导致更多利用再生废水作为作物灌溉的替代性和可靠来源。除了微生物的安全性以外，人们还对包括药物在内的异种生物污染回收废水产生了担忧。这项研究的重点是卡马西平，这是一种抗惊厥药，在回收废水中普遍检测到，在土壤中具有高度持久性，并被农作物吸收。在一项随机对照试验中，我们证明了健康的个体在其尿液中摄入回收的污水灌溉产品会排出卡马西平及其代谢产物，而食用淡水灌溉的受试者则会排出无法检测到的卡马西平或水平明显降低。我们还报告了在这种低暴露水平下的卡马西平代谢产物模式与在治疗剂量下观察到的模式不同。这项“概念验证”研究表明，人类摄入异种生物是通过摄入回收的废水灌溉产品而产生的，提供了现实世界的数据，可以指导风险评估和旨在确保废水安全用于农作物灌溉的政策。

著录项

  • 来源
    《Environmental Science & Technology》 |2016年第8期|4476-4482|共7页
  • 作者

    Ora Paltiel; Ganna Fedorova; Galit Tadmor; Geffen Kleinstern; Yehoshua Maor; Benny Chefetz;

  • 作者单位

    Braun School of Public Health and Community Medicine, Hadassah-Hebrew University of Jerusalem, Jerusalem 9112001, Israel ,Department of Hematology, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, Israel ,The Hebrew University Center of Excellence in Agriculture and Environmental Health;

    The Hebrew University Center of Excellence in Agriculture and Environmental Health ,Department of Soil and Water Sciences, Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel;

    Braun School of Public Health and Community Medicine, Hadassah-Hebrew University of Jerusalem, Jerusalem 9112001, Israel ,The Hebrew University Center of Excellence in Agriculture and Environmental Health ,Department of Soil and Water Sciences, Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel;

    Braun School of Public Health and Community Medicine, Hadassah-Hebrew University of Jerusalem, Jerusalem 9112001, Israel ,The Hebrew University Center of Excellence in Agriculture and Environmental Health;

    The Hebrew University Center of Excellence in Agriculture and Environmental Health;

    The Hebrew University Center of Excellence in Agriculture and Environmental Health ,Department of Soil and Water Sciences, Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号