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首页> 外文期刊>Environmental Science & Technology >Physiological and Behavioral Effects of Exposure to Environmentally Relevant Concentrations of Prednisolone During Zebrafish (Danio rerio) Embryogenesis
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Physiological and Behavioral Effects of Exposure to Environmentally Relevant Concentrations of Prednisolone During Zebrafish (Danio rerio) Embryogenesis

机译：斑马鱼胚胎发育期间暴露于强的松龙的环境相关浓度的生理和行为影响

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摘要

The presence of synthetic glucocorticoids within the aquatic environment has been highlighted as a potential environmental concern as they may mimic the role of endogenous glucocorticoids during vertebrate ontogeny. Prednisolone is a commonly prescribed synthetic glucocorticoid which has been repeatedly detected in the environment. This study investigated the impact of environmentally relevant concentrations of prednisolone (0.1, 1, and 10 μg/L) during zebrafish embryogenesis using physiological and behavioral end points which are known to be mediated by endogenous glucocorticoids. The frequency of spontaneous muscle contractions (24 hpf) was significantly reduced by prednisolone and 0.1 μg/L increased the distance embryos swam in response to a mechanosensory stimulus (48 hpf). The percentage of embryos hatched significantly increased following prednisolone treatment (1 and 10 μg/L), while growth and mortality were unaffected. The onset of heart contraction was differentially affected by prednisolone while heart rate and oxygen consumption both increased significantly throughout embryogenesis. No substantial effect on the axial musculature was observed. Morphological changes to the lower jaw were detected at 96 hpf in response to 1 μg/L of prednisolone. Several parameters of swim behavior were also significantly affected. Environmentally relevant concentrations of prednisolone therefore alter early zebrafish ontogeny and significantly affect embryo behavior.
机译：水生环境中合成糖皮质激素的存在已被强调为潜在的环境问题，因为它们可能模仿脊椎动物个体发育过程中内源性糖皮质激素的作用。泼尼松龙是通常处方的合成糖皮质激素，已在环境中反复检测到。这项研究使用已知由内源性糖皮质激素介导的生理和行为终点研究了环境相关浓度的泼尼松龙（0.1、1和10μg/ L）在斑马鱼胚胎发生过程中的影响。泼尼松龙可显着降低自发性肌肉收缩的频率（24 hpf），响应机械感官刺激（48 hpf），胚胎游动的距离增加0.1μg/ L。泼尼松龙处理后孵出的胚胎百分比显着增加（分别为1和10μg/ L），而生长和死亡率未受影响。泼尼松龙可不同程度地影响心脏收缩的发作，而在整个胚胎发生过程中，心率和耗氧量均显着增加。没有观察到对轴向肌肉组织的实质性影响。响应1μg/ L泼尼松龙，在96 hpf处检测到下颌的形态变化。游泳行为的几个参数也受到显着影响。因此，与环境有关的强的松龙的浓度会改变斑马鱼的早期个体发育，并显着影响胚胎的行为。

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  • 来源
    《Environmental Science & Technology》 |2016年第10期|5294-5304|共11页
  • 作者

    Paul L. McNeil; Carolina Nebot; Katherine A. Sloman;

  • 作者单位

    Institute of Biomedical and Environmental Health Research, School of Science and Sport, University of the West of Scotland, Paisley, U.K.;

    Department of Analytical Chemistry, Nutrition and Bromatology, Faculty of Veterinary Medicine, University of Santiago de Compostela, Lugo, Spain;

    Institute of Biomedical and Environmental Health Research, School of Science and Sport, University of the West of Scotland, Paisley, U.K.;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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