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首页> 外文期刊>Environmental Science & Technology >Fluoxetine Exhibits Pharmacological Effects and Trait-Based Sensitivity in a Marine Worm
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Fluoxetine Exhibits Pharmacological Effects and Trait-Based Sensitivity in a Marine Worm

机译：氟西汀在海洋蠕虫中表现出药理作用和基于性状的敏感性

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摘要

Global production of pharmacologically active compounds exceeds 100 000 tons annually, a proportion of which enters aquatic environments through patient use, improper medicine disposal, and production. These compounds are designed to have mode-of-action (MoA) effects on specific biological pathways, with potential to impact nontarget species. Here, we used MoA and trait-based approaches to quantify uptake and biological effects of fluoxetine, a selective serotonin reuptake inhibitor, in filter and deposit feeding marine worms (Hediste diversicolor). Worms exposed to 10 μg L~(-1), accumulated fluoxetine with a body burden over 270 times greater than exposure concentrations, resulting in ～10% increased coelomic fluid serotonin, a pharmacological effect. Observed effects included weight loss (up to 2% at 500 μg L~(-1)), decreased feeding rate (68% at 500 μg L~(-1)), and altered metabolism (oxygen consumption, ammonia excretion, and O/N from 10 μg L~(-1)). Bioconcentration of fluoxetine was dependent on route of uptake, with filter feeding worms experiencing up to 130 times greater body burden ratios and increased magnitudes of effects than deposit feeders, a trait-based sensitivity likely as a consequence of fluoxetine partitioning to sediment. This study highlights how novel approaches such as MoA and trait-based methods can supplement environmental risk assessments of pharmaceuticals.
机译：全球药理活性化合物的年产量超过10万吨，其中一部分通过患者使用，药物处置不当和生产而进入水生环境。这些化合物被设计为对特定的生物途径具有作用模式（MoA）效应，并可能影响非目标物种。在这里，我们使用MoA和基于特征的方法来量化氟西汀（一种选择性的5-羟色胺再摄取抑制剂）在过滤器和沉积物摄食海蠕虫（Hediste diversicolor）中的摄取和生物学效应。蠕虫暴露于10μgL〜（-1）时会积聚氟西汀，其负担超过暴露浓度的270倍以上，从而导致Coelomic液体5-羟色胺增加约10％，具有药理作用。观察到的影响包括体重减轻（在500μgL〜（-1）时高达2％），进食率降低（在500μgL〜（-1）时68％）和新陈代谢改变（耗氧量，氨排泄和O / N从10μgL〜（-1））。氟西汀的生物浓度取决于摄取途径，滤食性蠕虫的身体负担比和沉积物饲喂器相比，其最高高达130倍的负荷率和更大的作用强度，这可能是由于氟西汀分配给沉积物而导致的基于特征的敏感性。这项研究强调了MoA和基于特征的方法等新颖方法如何补充药物的环境风险评估。

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  • 来源
    《Environmental Science & Technology》 |2016年第15期|8344-8352|共9页
  • 作者

    Cameron M. Hird; Mauricio A. Urbina; Ceri N. Lewis; Jason R. Snape; Tamara S. Galloway;

  • 作者单位

    Department of Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, EX4 4QD, United Kingdom;

    Department of Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, EX4 4QD, United Kingdom,Departamento de Zoologia, Facultad de Ciencias Naturales y Oceanograficas, Universidad de Concepcion, P.O. Box 460-C, Concepcion, Chile;

    Department of Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, EX4 4QD, United Kingdom;

    AstraZeneca Global Environment, Alderley Park, Macclesfield, SK10 4TF, United Kingdom;

    Department of Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, EX4 4QD, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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