...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Linking Oxidative Stress and Magnitude of Compensatory Responses with Life-Stage Specific Differences in Sensitivity of White Sturgeon (Acipenser transmontanus) to Copper or Cadmium
【24h】

Linking Oxidative Stress and Magnitude of Compensatory Responses with Life-Stage Specific Differences in Sensitivity of White Sturgeon (Acipenser transmontanus) to Copper or Cadmium

机译：将氧化应激和代偿反应的幅度与白urge鱼（Acipenser transmontanus）对铜或镉的敏感性的终生特定差异联系起来

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sensitivity of white sturgeon (Acipenser transmontanus) to copper (Cu) or cadmium (Cd) has been shown to significantly differ as a function of life-stage. This study investigated oxidative stress, metal homeostasis, and associated compensatory responses as potential mechanisms of this sensitivity pattern in three early life-stages. Sturgeon were most sensitive to Cu at 15 days post hatch (dph), which was accompanied by a significant increase in lipid peroxidation (LPO). Genes involved with amelioration of oxidative stress were significantly less inducible at this stage than in older, less sensitive fry. At 48 dph, acute lethality of sturgeon exposed to Cd was greatest and body LPO was significantly induced by 3.5-fold at 5 μg Cd/L. Moreover, there was a small but significant increase in antioxidative responses. At 139 dph, sturgeon were most tolerant to Cu and Cd and accumulation of these metals was least. Also, expression of metallothionein (MT) and apoptotic genes were greatest while expression of metal transporters was reduced and concentration of LPO was not different from controls. Our results suggest that life-stage specific sensitivity of white sturgeon to metals is complex, encompassing differences in the ability to mount compensatory responses important for metal homeostasis and combating oxidative stress and concomitant damages.
机译：研究表明，白st鱼（Acipenser transmontanus）对铜（Cu）或镉（Cd）的敏感性随生命周期的变化而显着不同。这项研究调查了氧化应激，金属稳态和相关的补偿反应，作为在三个生命早期阶段这种敏感性模式的潜在机制。 hat鱼在孵化后第15天（dph）对Cu最敏感，这伴随着脂质过氧化（LPO）的显着增加。与较早的，敏感性较低的鱼苗相比，与氧化应激改善有关的基因在此阶段的诱导能力明显较低。在48 dph时，暴露于Cd的st鱼的急性致死率最高，在5μgCd / L时，体LPO被3.5倍显着诱导。而且，抗氧化反应有少量但显着的增加。在139 dph时，st鱼对Cu和Cd的耐受性最高，而这些金属的积累最少。同样，金属硫蛋白（MT）和凋亡基因的表达最大，而金属转运蛋白的表达减少，LPO的浓度与对照组无差异。我们的结果表明，白st鱼对金属的生命周期特异性敏感性很复杂，其中包括对金属稳态起重要补偿作用的能力的差异，以及应对氧化应激和随之而来的损害的能力。

著录项

  • 来源
    《Environmental Science & Technology》 |2016年第17期|9717-9726|共10页
  • 作者

    Song Tang; Jon A. Doering; Jianxian Sun; Shawn C. Beitel; Kamran Shekh; Sarah Patterson; Sarah Crawford; John P. Giesy; Steve B. Wiseman; Markus Hecker;

  • 作者单位

    School of Environment and Sustainability, University of Saskatchewan, Saskatoon, SK S7N 5C8, Canada;

    Toxicology Centre, University of Saskatchewan, Saskatoon, SK S7N SB3, Canada,Toxicology Graduate Program, University of Saskatchewan, Saskatoon, SK S7N 5B3, Canada;

    Toxicology Centre, University of Saskatchewan, Saskatoon, SK S7N SB3, Canada;

    Toxicology Centre, University of Saskatchewan, Saskatoon, SK S7N SB3, Canada,Toxicology Graduate Program, University of Saskatchewan, Saskatoon, SK S7N 5B3, Canada;

    Toxicology Centre, University of Saskatchewan, Saskatoon, SK S7N SB3, Canada,Toxicology Graduate Program, University of Saskatchewan, Saskatoon, SK S7N 5B3, Canada;

    Toxicology Centre, University of Saskatchewan, Saskatoon, SK S7N SB3, Canada,Toxicology Graduate Program, University of Saskatchewan, Saskatoon, SK S7N 5B3, Canada;

    Toxicology Centre, University of Saskatchewan, Saskatoon, SK S7N SB3, Canada,Toxicology Graduate Program, University of Saskatchewan, Saskatoon, SK S7N 5B3, Canada;

    Toxicology Centre, University of Saskatchewan, Saskatoon, SK S7N SB3, Canada,Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, SK S7N 5B4, Canada,Zoology Department, Center for Integrative Toxicology, Michigan State University, East Lansing, Michigan 48824, United States,School of Biological Sciences, University of Hong Kong, Hong Kong, SAR 999077, China,Department of Biology, Hong Kong Baptist University, Hong Kong, SAR 999077, China;

    Toxicology Centre, University of Saskatchewan, Saskatoon, SK S7N SB3, Canada,;

    School of Environment and Sustainability, University of Saskatchewan, Saskatoon, SK S7N 5C8, Canada,Toxicology Centre, University of Saskatchewan, Saskatoon, SK S7N SB3, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号