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Systematic and Day-to-Day Effects of Chemical-Derived Population Estimates on Wastewater-Based Drug Epidemiology

机译:化学衍生种群估计对基于废水的药物流行病学的系统和日常影响

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摘要

Population size is crucial when estimating population-normalized drug consumption (PNDC) from wastewater-based drug epidemiology (WBDE). Three conceptually different population estimates can be used: de jure (common census, residence), de facto (all persons within a sewer catchment), and chemical loads (contributors to the sampled wastewater). De facto and chemical loads will be the same where all households contribute to a central sewer system without wastewater loss. This study explored the feasibility of determining a de facto population and its effect on estimating PNDC in an urban community over an extended period. Drugs and other chemicals were analyzed in 311 daily composite wastewater samples. The daily estimated de facto population (using chemical loads) was on average 32% higher than the de jure population. Consequently, using the latter would systemically overestimate PNDC by 22%. However, the relative day-to-day pattern of drug consumption was similar regardless of the type of normalization as daily illicit drug loads appeared to vary substantially more than the population. Using chemical loads population, we objectively quantified the total methodological uncertainty of PNDC and reduced it by a factor of 2. Our study illustrated the potential benefits of using chemical loads population for obtaining more robust PNDC data in WBDE.
机译:从基于废水的药物流行病学(WBDE)估算人群标准化药物消费量(PNDC)时,人口规模至关重要。可以使用三种在概念上不同的人口估计值:法律上的(普查,居住),事实上的人(下水道集水区中的所有人)和化学负荷(取样废水的来源)。在所有家庭都为中央下水道系统做出贡献而不会造成废水损失的情况下,实际和化学负荷将是相同的。这项研究探讨了确定一个实际人口的可行性及其在较长时期内对估计城市社区PNDC的影响。每天对311份复合废水样品中的药物和其他化学品进行分析。每日估计的实际人口(使用化学药品)平均比法律上的人口高32%。因此,使用后者会系统性地将PNDC高估22%。但是,无论正常化类型如何,相对的日常用药模式都是相似的,因为每日非法药物负荷似乎比人口变化大得多。通过使用化学负载总量,我们客观地量化了PNDC的总体方法学不确定性,并将其降低了2倍。我们的研究说明了使用化学负载总量在WBDE中获取更可靠的PNDC数据的潜在好处。

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  • 来源
    《Environmental Science & Technology》 |2015年第2期|999-1008|共10页
  • 作者单位

    The National Research Centre for Environmental Toxicology, The University of Queensland, 39 Kessels Road, Coopers Plains QLD 4108, Australia;

    The National Research Centre for Environmental Toxicology, The University of Queensland, 39 Kessels Road, Coopers Plains QLD 4108, Australia,Queensland Health Forensic Scientific Services, Queensland Government, 39 Kessels Road, Coopers Plains QLD 4108, Australia;

    School of Medicine (Psychology), University of Tasmania, Private Bag 30, Hobart TAS 7001, Australia;

    Queensland Health Forensic Scientific Services, Queensland Government, 39 Kessels Road, Coopers Plains QLD 4108, Australia;

    Centre for Clinical Research, Royal Brisbane and Women's Hospital, The University of Queensland, Herston QLD 4029, Australia;

    Centre for Youth Substance Abuse Research, Royal Brisbane and Women's Hospital, The University of Queensland, Herston QLD 4029, Australia;

    School of Chemical and Physical Sciences, Flinders University, Adelaide SA 5001, Australia;

    The National Research Centre for Environmental Toxicology, The University of Queensland, 39 Kessels Road, Coopers Plains QLD 4108, Australia;

    The National Research Centre for Environmental Toxicology, The University of Queensland, 39 Kessels Road, Coopers Plains QLD 4108, Australia;

    Faculty of Law, University of Tasmania, Private Bag 89, Hobart TAS 7001, Australia;

    The National Research Centre for Environmental Toxicology, The University of Queensland, 39 Kessels Road, Coopers Plains QLD 4108, Australia;

    Urban Water Management, Swiss Federal Institute of Aquatic Science and Technology (Eawag) , Ueberlandstrasse 133, CH 8600 Duebendorf, Switzerland,Advanced Water Management Centre (AWMC), The University of Queensland, Brisbane QLD 4072, Australia;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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