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首页> 外文期刊>Environmental Science & Technology >Benzo(a)pyrene Metabolism and EROD and GST Biotransformation Activity in the Liver of Red- and White-Blooded Antarctic Fish
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Benzo(a)pyrene Metabolism and EROD and GST Biotransformation Activity in the Liver of Red- and White-Blooded Antarctic Fish

机译：南极红白血鱼肝脏中的苯并zo代谢及EROD和GST生物转化活性

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摘要

Climate change and anthropogenic pollution are of increasing concern in remote areas such as Antarctica. The evolutionary adaptation of Antarctic notothenioid fish to the cold and stable Southern Ocean led to a low plasticity of their physiological functions, what may limit their capacity to deal with altered temperature regimes and pollution in the Antarctic environment. Using a biochemical approach, we aimed to assess the hepatic biotransformation capacities of Antarctic fish species by determining (ⅰ) the activities of ethoxyresorufin-O-deethylase (EROD) and glutathione-S-trans- ferase (GST), and (ⅱ) the metabolic clearance of benzo(a)pyrene by hepatic S9 supernatants. In addition, we determined the thermal sensitivity of the xenobiotic biotransformation enzymes. We investigated the xenobiotic metabolism of the red-blooded Gobionotothen gibberifrons and Notothenia rossii, the hemoglobin-less Chaenocephalus aceratus and Champsocephalus gunnari, and the rainbow trout Oncorhynchus mykiss as a reference. Our results revealed similar metabolic enzyme activities and metabolic clearance rates between red- and white-blooded Antarctic fish, but significantly lower rates in comparison to rainbow trout. Therefore, bioaccumulation factors for metabolizable lipophitic contaminants may be higher in Antarctic than in temperate fish. Likewise, the thermal adaptive capacities and flexibilities of the EROD and GST activities in Antarctic fish were significantly lower than in rainbow trout. As a consequence, increasing water temperatures in the Southern Ocean will additionally compromise the already low detoxification capacities of Antarctic fish.
机译：在偏远地区，如南极洲，气候变化和人为污染日益受到关注。南极类胡萝卜素鱼类在寒冷和稳定的南洋中的进化适应导致其生理功能的可塑性较低，这可能限制了它们应对南极环境温度变化和污染的能力。通过生化方法，我们旨在通过确定（ⅰ）乙氧基间苯二酚-O-脱乙基酶（EROD）和谷胱甘肽-S-转移酶（GST）的活性，以及​​（ⅱ）评估南极鱼类的肝脏生物转化能力。肝S9上清液对苯并（a）re的代谢清除率此外，我们确定了异种生物转化酶的热敏感性。我们研究了血红的赤霉素和罗氏诺斯氏菌，无血红蛋白的鹿角菌和色氏Champsocephalus gunnari，以及虹鳟Oncorhynchus mykiss的异种生物代谢。我们的研究结果表明，红，白血南极鱼的代谢酶活性和代谢清除率相似，但与虹鳟鱼相比，代谢率明显更低。因此，南极地区可代谢的脂类污染物的生物蓄积因子可能比温带鱼类更高。同样，南极鱼的EROD和GST活动的热适应能力和柔韧性明显低于虹鳟鱼。结果，南大洋中水温的升高将进一步损害南极鱼本来就很低的排毒能力。

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  • 来源
    《Environmental Science & Technology》 |2015年第13期|8022-8032|共11页
  • 作者

    Anneli Strobel; Patricia Burkhardt-Holm; Peter Schmid; Helmut Segner;

  • 作者单位

    University of Basel, Departement of Environmental Sciences, Programme Man-Society-Environment MGU, Vesalgasse 1, CH-4051 Basel, Switzerland,University of Bern, Vetsuisse Faculty, Centre for Fish and Wildlife Health, Laenggassstrasse 12, CH-3012 Bern, Switzerland;

    University of Basel, Departement of Environmental Sciences, Programme Man-Society-Environment MGU, Vesalgasse 1, CH-4051 Basel, Switzerland,Department of Biological Sciences, University of Alberta, Edmonton, Alberta T6G 2R3, Canada;

    Empa, Swiss Federal Laboratories for Materials Science and Technology, UEberlandstrasse 129, CH-8600 Duebendorf, Switzerland;

    University of Bern, Vetsuisse Faculty, Centre for Fish and Wildlife Health, Laenggassstrasse 12, CH-3012 Bern, Switzerland;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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