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首页> 外文期刊>Environmental Science & Technology >Exposure to Deepwater Horizon Crude Oil Burnoff Particulate Matter Induces Pulmonary Inflammation and Alters Adaptive Immune Response
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Exposure to Deepwater Horizon Crude Oil Burnoff Particulate Matter Induces Pulmonary Inflammation and Alters Adaptive Immune Response

机译：暴露于深水地平线原油燃尽颗粒物会引起肺部炎症并改变适应性免疫反应

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摘要

The "in situ burning" of trapped crude oil on the surface of Gulf waters during the 2010 Deepwater Horizon (DWH) oil spill released numerous pollutants, including combustion-generated particulate matter (PM). Limited information is available on the respiratory impact of inhaled in situ burned oil sail particulate matter (OSPM). Here we utilized PM collected from in situ bum plumes of the DWH oil spill to study the acute effects of exposure to OSPM on pulmonary health. OSPM caused dose-and time-dependent cytotoxicity and generated reactive oxygen species and superoride radicals in vitro. Additionally, mice exposed to OSPM exhibited significant decreases in body weight gain, systemic oxidarive stress in the form of increased serum 8-isoprostane (8-IP) levels, and airway inflammation in the form of increased macrophages and eosinophils in bronchoalveolar lavage fluid. Further, in a mouse model of allergic asthma, OSPM caused increased T helper 2 cells (Th2), peribronchiolar inflammation, and increased airway mucus production. These findings demonstrate that acute exposure to OSPM results in pulmonary inflammation and alteration of innate/adaptive immune responses in mice and highlight potential respiratory effects associated with cleaning up an oil spill.
机译：在2010年“深水地平线”（DWH）溢油事故中，海湾水域表面被困原油的“原位燃烧”释放了许多污染物，其中包括燃烧产生的颗粒物（PM）。关于吸入的现场燃烧的油帆颗粒物（OSPM）的呼吸影响的信息有限。在这里，我们利用从DWH溢油现场烟雾中收集的PM来研究OSPM暴露对肺健康的急性影响。 OSPM引起剂量和时间依赖性的细胞毒性，并在体外产生活性氧和超氧自由基。此外，暴露于OSPM的小鼠的体重增加显着降低，以血清8-异前列腺素（8-IP）水平升高的形式出现全身性氧化应激，以支气管肺泡灌洗液中巨噬细胞和嗜酸性粒细胞形式出现气道炎症。此外，在过敏性哮喘的小鼠模型中，OSPM引起T辅助2细胞（Th2）增加，细支气管周围发炎和气道粘液产生增加。这些发现表明，OSPM的急性暴露会导致小鼠的肺部炎症和先天/适应性免疫反应的改变，并突出显示与清理溢油有关的潜在呼吸作用。

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  • 来源
    《Environmental Science & Technology》 |2015年第14期|8769-8776|共8页
  • 作者

    Sridhar Jaligama; Zaili Chen; Jordy Saravia; Nikki Yadav; Slawomir M. Lomnicki; Tammy R. Dugas; Stephania A. Cormier;

  • 作者单位

    Department of Pediatrics, University of Tennessee Health Science Center, 50 North Dunlap Street, Memphis, Tennessee 38103, United States,Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana 70803;

    Children's Foundation Research Institute, Le Bonheur Children's Hospital, Memphis, Tennessee 38103, United States;

    Department of Pediatrics, University of Tennessee Health Science Center, 50 North Dunlap Street, Memphis, Tennessee 38103, United States,Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana 70803;

    Department of Pediatrics, University of Tennessee Health Science Center, 50 North Dunlap Street, Memphis, Tennessee 38103, United States,Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana 70803;

    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, United States;

    Department of Environmental Sciences, Louisiana State University, Baton Rouge, Louisiana 70803, United States;

    Department of Pediatrics, University of Tennessee Health Sciences Center, Le Bonheur Children's Hospital, Children's Foundation Research Institute, 50 N Dunlap, Room 466R, Memphis, TN 38103,Department of Pediatrics, University of Tennessee Health Science Center, 50 North Dunlap Street, Memphis, Tennessee 38103, United States,Department of Comparative Biomedical Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, Louisiana 70803;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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