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首页> 外文期刊>Environmental Science & Technology >Mitigation in Multiple Effects of Graphene Oxide Toxicity in Zebrafish Embryogenesis Driven by Humic Acid
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Mitigation in Multiple Effects of Graphene Oxide Toxicity in Zebrafish Embryogenesis Driven by Humic Acid

机译：腐殖酸驱动的斑马鱼胚胎发育中氧化石墨烯毒性多重影响的缓解

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摘要

Graphene oxide (GO) is a widely used carbonaceous nanomaterial. To date, the influence of natural organic matter (NOM) on GO toxicity in aquatic vertebrates has not been reported During zebrafish embryogenesis, GO induced a significant hatching delay and cardiac edema. The intensive interactions of GO with the chorion induces damage to chorion protuberances, excessive generation of ~•OH, and changes in protein secondary structure. In contrast, humic acid (HA), a ubiquitous form of NOM, significantly relieved the above adverse effects. HA reduced the interactions between GO and the chorion and mitigated chorion damage by regulating the morphology, structures, and surface negative charges of GO. HA also altered the uptake and deposition of GO and decreased the aggregation of GO in embryonic yolk cells and deep layer cells. Furthermore, HA mitigated the mitochondrial damage and oxidative stress induced by GO. This work reveals a feasible antidotal mechanism for GO in the presence of NOM and avoids overestimating the risks of GO in the natural environment.
机译：氧化石墨烯（GO）是一种广泛使用的碳纳米材料。迄今为止，尚未报道天然有机物（NOM）对水生脊椎动物GO毒性的影响。在斑马鱼胚胎发生过程中，GO引起了明显的孵化延迟和心脏水肿。 GO与绒毛膜的强烈相互作用会导致绒毛膜突起的损坏，〜•OH的过量生成以及蛋白质二级结构的变化。相反，普遍存在的NOM腐殖酸（HA）可以大大减轻上述不利影响。 HA通过调节GO的形态，结构和表面负电荷来减少GO与绒毛膜之间的相互作用并减轻绒毛膜损伤。 HA还改变了GO在胚胎卵黄细胞和深层细胞中的摄取和沉积，并降低了GO的聚集。此外，HA减轻了GO诱导的线粒体损伤和氧化应激。这项工作揭示了在存在NOM的情况下GO可行的解毒机制，并避免了高估GO在自然环境中的风险。

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  • 来源
    《Environmental Science & Technology》 |2015年第16期|10147-10154|共8页
  • 作者

    Yuming Chen; Chaoxiu Ren; Shaohu Ouyang; Xiangang Hu; Qixing Zhou;

  • 作者单位

    Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education)/Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China;

    Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education)/Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China;

    Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education)/Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China;

    Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education)/Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China;

    Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education)/Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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