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首页> 外文期刊>Environmental Science & Technology >Bacterial Community Shift Drives Antibiotic Resistance Promotion during Drinking Water Chlorination
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Bacterial Community Shift Drives Antibiotic Resistance Promotion during Drinking Water Chlorination

机译：饮用水氯化过程中细菌群落的变化促进抗生素耐药性的提高

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摘要

For comprehensive insights into the effects of chlorination, a widely used disinfection technology, on bacterial community and antibiotic resistome in drinking water, this study applied high-throughput sequencing and metagenomic approaches to investigate the changing patterns of antibiotic resistance genes (ARGs) and bacterial community in a drinking water treatment and distribution system. At genus level, chlorination could effectively remove Methylophilus, Methyl- otenera, Limnobacter, and Polynucleobacter, while increase the relative abundance of Pseudomonas, Acidovorax, Sphingomonas, Pleomonas, and Undtbaderium in the drinking water. A total of 151 ARGs within 15 types were detectable in the drinking water, and chlorination evidently increased their total relative abundance while reduced their diversity in the opportunistic bacteria (p ＜ 0.05). Residual chlorine was identified as the key contributing factor driving the bacterial community shift and resistome alteration. As the dominant persistent ARGs in the treatment and distribution system, multidrug resistance genes (mainly encoding resistance-nodulation-cell division transportation system) and bacitracin resistance gene bacA were mainly carried by chlorine-resistant bacteria Pseudomonas and Acidovorax, which mainly contributed to the ARGs abundance increase. The strong correlation between bacterial community shift and antibiotic resistome alteration observed in this study may shed new light on the mechanism behind the chlorination effects on antibiotic resistance.
机译：为了全面了解广泛使用的消毒技术氯化对饮用水中细菌群落和抗生素抵抗力组的影响，本研究采用高通量测序和宏基因组学方法研究了抗生素抗性基因（ARG）和细菌群落的变化模式在饮用水处理和分配系统中。在属水平上，氯化可有效去除饮用水中的嗜甲基菌，甲基小肠膜菌，线菌和多核杆菌，同时增加饮用水中假单胞菌，嗜酸菌，鞘氨醇单胞菌，滑膜单胞菌和Undtbaderium的相对丰度。在饮用水中可检测到15种类型的151种ARG，氯化明显增加了它们的总相对丰度，同时减少了机会细菌中的多样性（p ＜0.05）。残留的氯被确定为驱动细菌群落转移和抵抗力改变的关键因素。作为治疗和分配系统中的主要持久性ARG，多药耐药基因（主要编码耐药-结节-细胞分裂转运系统）和杆菌肽耐药基因bacA主要由耐氯细菌Pseudomonas和Acidovorax携带，这主要是对ARGs的贡献丰度增加。在这项研究中观察到的细菌群落转移和抗生素抵抗力变化之间的强相关性可能为氯化作用对抗生素抵抗的背后机制提供了新的启示。

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  • 来源
    《Environmental Science & Technology》 |2015年第20期|12271-12279|共9页
  • 作者

    Shuyu Jia; Peng Shi; Qing Hu; Bing Li; Tong Zhang; Xu-Xiang Zhang;

  • 作者单位

    State Key Laboratory of Pollution Control and Resource Reuse, Environmental Health Research Center, School of the Environment, Nanjing University, Nanjing 210023, China;

    State Key Laboratory of Pollution Control and Resource Reuse, Environmental Health Research Center, School of the Environment, Nanjing University, Nanjing 210023, China;

    State Key Laboratory of Pollution Control and Resource Reuse, Environmental Health Research Center, School of the Environment, Nanjing University, Nanjing 210023, China;

    Environmental Biotechnology Lab, Department of Civil Engineering, The University of Hong Kong, Hong Kong SAR, China;

    Environmental Biotechnology Lab, Department of Civil Engineering, The University of Hong Kong, Hong Kong SAR, China;

    State Key Laboratory of Pollution Control and Resource Reuse, Environmental Health Research Center, School of the Environment, Nanjing University, Nanjing 210023, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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