...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Application of the Activity Framework for Assessing Aquatic Ecotoxicology Data for Organic Chemicals
【24h】

Application of the Activity Framework for Assessing Aquatic Ecotoxicology Data for Organic Chemicals

机译：活动框架在评估有机化学品水生生态毒理学数据中的应用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Toxicological research in the 1930s gave the first indications of the link between narcotic toxicity and the chemical activity of organic chemicals. More recently, chemical activity has been proposed as a novel exposure parameter that describes the fraction of saturation and that quantifies the potential for partitioning and diffusive uptake. In the present study, more than 2000 acute and chronic algal, aquatic invertebrates and fish toxicity data, as well as water solubility and melting point values, were collected from a series of sources. The data were critically reviewed and grouped by mode of action (MoA). We considered 660 toxicity data to be of acceptable quality. The 328 data which applied to the 72 substances identified as MoA 1 were then evaluated within the activity-toxicity framework: EC50 and LC50 values for all three taxa correlated generally well with (subcooled) liquid solubilities. Acute toxicity was typically exerted within the chemical activity range of 0.01-0.1, whereas chronic toxicity was exerted in the range of 0.001-0.01. These results confirm that chemical activity has the potential to contribute to the determination, interpretation and prediction of toxicity to aquatic organisms. It also has the potential to enhance regulation of organic chemicals by linking results from laboratory tests, monitoring and modeling programs. The framework can provide an additional line of evidence for assessing aquatic toxicity, for improving the design of toxicity tests, reducing animal usage and addressing chemical mixtures.
机译：1930年代的毒理学研究首次表明了麻醉毒性与有机化学物质之间的联系。最近，化学活性已经被提出作为一种新颖的暴露参数，该参数描述了饱和度的分数并量化了分配和扩散吸收的潜力。在本研究中，从一系列来源收集了2000多个急性和慢性藻类，水生无脊椎动物和鱼类毒性数据以及水溶性和熔点值。严格审查数据并按作用模式（MoA）分组。我们认为660种毒性数据具有可接受的质量。然后，在活性毒性框架内评估了应用于72种被鉴定为MoA 1的328种数据：所有三个分类单元的EC50和LC50值通常与（过冷的）液体溶解度相关。急性毒性通常在0.01-0.1的化学活性范围内发挥作用，而慢性毒性则在0.001-0.01的化学活性范围内发挥作用。这些结果证实化学活性有可能有助于确定，解释和预测对水生生物的毒性。通过将实验室测试，监测和建模程序的结果联系起来，它还具有增强有机化学物质监管的潜力。该框架可以为评估水生毒性，改善毒性试验的设计，减少动物的使用和处理化学混合物提供额外的证据。

著录项

  • 来源
    《Environmental Science & Technology》 |2015年第20期|12289-12296|共8页
  • 作者

    Paul Thomas; James Dawick; Mark Lampi; Philippe Lemaire; Shaun Presow; Roger van Egmond; Jon A. Arnot; Donald Mackay; Philipp Mayer; Malyka Galay Burgos;

  • 作者单位

    CEHTRA/KREATiS, ZAC de Saint Hubert, 23 rue du Creuzat, 38080 L'Isle d'Abeau, France;

    Shell Health, Brabazon House, Concord Business Park, Manchester, Greater Manchester, M22 0RR, United Kingdom;

    ExxonMobil Biomedical Sciences, Inc., 1545 US 22 East, Annandale, New Jersey 08801, United States;

    Total Fluides, 24 Cours Michelet - La Defense 10, F-92069, Paris La Defense Cedex, France;

    Euro Chlor, Avenue E. Van Nieuwenhuyse 4, B-1160 Brussels, Belgium;

    Unilever, Colworth Science Park, Sharnbrook, Bedford, Bedfordshire MK44 1LQ, United Kingdom;

    ARC Arnot Research & Consulting Inc., 36 Sproat Avenue, Toronto, ON M4M 1W4, Canada;

    Trent University, 1600 West Bank Drive, Peterborough, Ontario K9J 7B8, Canada;

    Technical University of Denmark, Department of Environmental Engineering, Lyngby, Denmark;

    European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), Avenue E. Van Nieuwenhuyse 2, B-1160 Brussels, Belgium;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号