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首页> 外文期刊>Environmental Science & Technology >Dose-Dependent Early Life Stage Toxicities in Xenopus laevis Exposed In Ovo to Selenium
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Dose-Dependent Early Life Stage Toxicities in Xenopus laevis Exposed In Ovo to Selenium

机译：Xenopus laevis的剂量依赖性生命早期毒性暴露于硒中。

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摘要

Selenium (Se) is a developmental toxicant in oviparous vertebrates. The adverse reproductive effects of Se toxicity have been predominantly investigated in fishes and birds with only a few studies focusing on amphibians. The objective of this study was to determine tissue-based toxicity thresholds for early life stage Se toxicities in Xenopus laevis as a consequence of in ovo exposure through maternal transfer of dietary Se. Following a 68-day dietary exposure to food augmented with L- selenomethionine (SeMet) at measured concentrations of 0.7 (control), 10.9, 30.4, or 94.2 μg Se/g dry mass (d.m.), adult female X. laevis were bred with untreated males, and resulting embryos were incubated until 5 days postfertilization (dpf). The measured Se concentrations in eggs were 1.6, 10.8, 28.1, and 81.7 μg Se/g dm., respectively. No biologically significant effects were observed on fertilization success, hatchability, or mortality in offspring. Frequency and severity of morphological abnormalities were significantly greater in 5 dpf tadpoles from the highest exposure group when compared to the control, with eye lens abnormalities being the most prominent of all abnormalities. The estimated EC_(10) value for frequency of total early life stage abnormalities was 44.9 μg Se/g egg d.m., which suggests that this amphibian species is less sensitive to in ovo Se exposure than most of the fish species studied to date.
机译：硒（Se）是卵生脊椎动物中的发育毒物。硒毒性的不利生殖作用主要在鱼类和鸟类中进行了研究，只有很少的研究集中在两栖动物上。这项研究的目的是确定非洲爪蟾生命周期早期硒毒性的基于组织的毒性阈值，这是由于母体通过饮食中硒的摄入引起的卵内暴露引起的。在饮食中暴露于浓度为0.7（对照），10.9、30.4或94.2μgSe / g干质量（dm）的L-硒代蛋氨酸（SeMet）的食物中，经过68天的饮食暴露后，将成年雌性X.laevis与未经处理的雄性，将得到的胚胎孵育至受精后5天（dpf）。鸡蛋中测得的硒浓度分别为1.6、10.8、28.1和81.7μgSe / g dm.。没有观察到对后代受精成功，孵化率或死亡率具有生物学意义的影响。与对照组相比，暴露量最高的5 dpf t中形态异常的频率和严重性明显更高，其中晶状体异常是所有异常中最突出的。整个生命早期异常频率的估计EC_（10）值为44.9μgSe / g鸡蛋d.m.，表明该两栖动物对卵内硒的暴露的敏感性低于迄今为止研究的大多数鱼类。

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  • 来源
    《Environmental Science & Technology》 |2015年第22期|13658-13666|共9页
  • 作者

    Anita J. Masse; Jorgelina R. Muscatello; David M. Janz;

  • 作者单位

    Toxicology Graduate Program, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B3;

    Stantec Consulting Ltd., Burnaby, British Columbia, Canada V5H 0C6;

    Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B3 ,Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B4;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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