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首页> 外文期刊>Environmental Science & Technology >An Ultrasensitive (Parts-Per-Quadrillion) and SPE-Free Method for the Quantitative Analysis of Estrogens in Surface Water
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An Ultrasensitive (Parts-Per-Quadrillion) and SPE-Free Method for the Quantitative Analysis of Estrogens in Surface Water

机译：超灵敏（每四分之一）和无固相萃取的定量分析地表水中雌激素的方法

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摘要

An analytical method is presented here that is sensitive to the parts-per-quadrillion (pg/L) for estrogens in surface water. The estrogens included for study were estrone, 17β-estradiol, estriol, 17α-ethinylestradiol, and equilin. The method consisted of the small-scale liquid-liquid extraction of surface water followed by derivation with dansyl chloride. Analyte separation and detection were performed by high-pressure liquid-chromatography and tandem mass-spectrome-try. A large volume (100 μL) of the sample was injected on-column to increase the analyte mass sent to the detector. The detection limits of the method were 0.045 ng/L for estrone, 0.086 ng/L for 17β-estradiol, 0.030 ng/L for estriol, 0.049 ng/ L for 17α-ethinylestradiol, and 0.13 ng/L for equilin. The whole-method accuracy ranged from 93 ± 5.8% to 105 ± 4.5% for all the analytes at two different spike levels. Similarly, the precision of the method was less than 8.0% relative standard deviation. The final method was used to analyze a series of samples from the Mississippi River spanning 51 river miles. Estrone was detected in all of the samples and 17β-estradiol was detected in one. Concentrations of estrone ranged from between the detection and quantification limits up to 0.63 ng/L. Increases in the concentration of estrone could be observed downstream from potential sources including a drinking water treatment plant. 17β-estradiol was detected below its quantitation limit in a sample taken downstream from a wastewater treatment plant.
机译：本文介绍了一种分析方法，该方法对地表水中的雌激素的百万分之几（pg / L）敏感。包括在研究中的雌激素是雌酮，17β-雌二醇，雌三醇，17α-炔雌醇和马雌激素。该方法包括对地表水进行小规模的液-液萃取，然后用丹磺酰氯进行衍生。通过高压液相色谱和串联质谱法进行分析物的分离和检测。大体积（100μL）的样品在色谱柱上进样，以增加发送到检测器的分析物质量。该方法的检出限为雌酮0.045 ng / L，17β-雌二醇0.086 ng / L，雌三醇0.030 ng / L，17α-乙炔雌二醇0.049 ng / L和马鞭草0.13 ng / L。在两种不同的加标水平下，所有分析物的整体方法精度范围从93±5.8％到105±4.5％。同样，该方法的精度相对标准偏差小于8.0％。最终方法用于分析密西西比河的一系列样本，这些样本跨越51英里。在所有样品中均检测到雌酮，在一个样品中检测出17β-雌二醇。雌酮的浓度范围介于检测限和定量限之间，最高可达0.63 ng / L。在包括饮用水处理厂在内的潜在来源的下游，可以观察到雌酮浓度的增加。在废水处理厂下游采集的样品中检测到17β-雌二醇低于其定量限。

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  • 来源
    《Environmental Science & Technology》 |2015年第24期|14311-14318|共8页
  • 作者

    Will J. Backe;

  • 作者单位

    Public Health Laboratory, Minnesota Department of Health, 601 Robert St. N., P.O. Box 64899, Saint Paul, Minnesota 55164-0899, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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