Human Exposure to Chlorinated Paraffins via Inhalation and Dust Ingestion in a Norwegian Cohort

Bo Yuan; Joo Hui Tay; Juan Antonio Padilla-Sanchez; Eleni Papadopoulou; Line Smastuen Haug; Cynthia A. de Wit

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Human Exposure to Chlorinated Paraffins via Inhalation and Dust Ingestion in a Norwegian Cohort

机译：人类暴露于氯化石蜡，通过吸入和尘埃摄入挪威队列

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Very-short- (vSCCPs, C_(6-9)), short- (SCCPs, C_(10-13)), medium- (MCCPs, C_(14-17)), and long-chain chlorinated paraffins (LCCPs, C_(＞17)) were analyzed in indoor air and dust collected from the living rooms and personal 24 h air of 61 adults from a Norwegian cohort. Relatively volatile CPs, i.e., vSCCPs and SCCPs, showed a greater tendency to partition from settled indoor dust to paired stationary indoor air from the same living rooms than MCCPs and LCCPs, with median logarithmic dust-air partition ratios of 1.3, 2.9, 4.1, and 5.4, respectively. Using the stationary indoor air and settled indoor dust concentrations, the combined median daily exposures to vSCCPs, SCCPs, MCCPs, and LCCPs were estimated to be 0.074, 2.7, 0.93, and 0.095 ng/kg bw/d, respectively. Inhalation was the predominant exposure pathway for vSCCPs (median 99%) and SCCPs (59%), while dust ingestion was the predominant exposure pathway for MCCPs (75%) and LCCPs (95%). The estimated inhalation exposure to total CPs was ～5 times higher when the personal 24 h air results were used rather than the corresponding stationary indoor air results in 13 paired samples, indicating that exposure situations other than living rooms contributed significantly to the overall personal exposure. The 95th percentile exposure for CPs did not exceed the reference dose.

机译：非常短 - （VSCCP，C_（6-9）），短（SCCP，C_（10-13）），中等 - （MCCP，C_（14-17））和长链氯化石蜡（LCCPS， C _（> 17）分析了从起居室收集的室内空气和尘埃，并从挪威队列的61名成人的个人24小时空气。相对挥发的CPS，即VSCCP和SCCP，从稳定的室内灰尘倾向于与MCCP和LCCP相同的客厅配对的静止室内空气，中值对数灰尘 - 空气隔离比为1.3,2.9,4.1，和5.4分别。使用静止室内空气和沉降的室内粉尘浓度，估计为VSCCPS，SCCP，MCCP和LCCP的组合中位曝光，分别为0.074,2.7,0.93和0.095ng / kg Bw / d。吸入是VSCCPS（中位数99％）和SCCP（59％）的主要暴露途径，而尘埃摄取是MCCPS（75％）和LCCPS（95％）的主要暴露途径。当使用个人24小时空气结果而不是相应的静止室内空气导致13种样品时，估计的吸入暴露于总CPS〜5倍，表明除了起居室以外的曝光情况，对整体个人接触的贡献显着贡献。 CPS的第95百分位暴露不超过参考剂量。

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《Environmental Science & Technology》 |2021年第2期|1145-1154|共10页
作者
Bo Yuan; Joo Hui Tay; Juan Antonio Padilla-Sanchez; Eleni Papadopoulou; Line Smastuen Haug; Cynthia A. de Wit;
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Department of Environmental Science Stockholm University SE-10691 Stockholm Sweden;

Department of Environmental Science Stockholm University SE-10691 Stockholm Sweden;

Section for Environmental Exposure and Epidemiology Norwegian Institute of Public Health NO-0213 Oslo Norway;

Section for Environmental Exposure and Epidemiology Norwegian Institute of Public Health NO-0213 Oslo Norway;

Section for Environmental Exposure and Epidemiology Norwegian Institute of Public Health NO-0213 Oslo Norway;

Department of Environmental Science Stockholm University SE-10691 Stockholm Sweden;

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Human Exposure to Chlorinated Paraffins via Inhalation and Dust Ingestion in a Norwegian Cohort

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