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首页> 外文期刊>Environmental Science & Technology >Assessing Human Exposure to SVOCs in Materials, Products, and Articles: A Modular Mechanistic Framework
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Assessing Human Exposure to SVOCs in Materials, Products, and Articles: A Modular Mechanistic Framework

机译：评估材料，产品和物品中SVOC的人体暴露：模块化机制框架

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摘要

A critical review of the current state of knowledge of chemical emissions from indoor sources, partitioning among indoor compartments, and the ensuing indoor exposure leads to a proposal for a modular mechanistic framework for predicting human exposure to semivolatile organic compounds (SVOCs). Mechanistically consistent source emission categories include solid, soft, frequent contact, applied,sprayed, and high temperature sources. Environmental compartments are the gas phase, airborne particles, settled dust, indoor surfaces, and clothing.Identified research needs are the development of dynamic emission models for several of the source emission categories and of estimation strategies for critical model parameters. The modular structure of the framework facilitates subsequent inclusion of new knowledge, other chemical classes of indoor pollutants, and additional mechanistic processes relevant to human exposure indoors. The framework may serve as the foundation for developing an open-source community model to better support collaborative research and improve access for application by stakeholders. Combining exposure estimates derived using this framework with toxicity data for different end points and toxicokinetic mechanisms will accelerate chemical risk prioritization,advance effective chemical management decisions, and protect public health.
机译：对来自室内源的化学排放的现状，室内隔间分区的批判性综述，随后的室内暴露导致用于预测人对半抗生素有机化合物（SVOC）的人体暴露的模块化机械框架的提议。机械化一致的源排放类别包括固体，柔软，频繁接触，施加，喷涂和高温源。环境隔间是气相，空气颗粒，沉降的灰尘，室内表面和服装。识别的研究需求是用于几个源排放类别的动态发射模型和关键模型参数的估算策略的发展。框架的模块化结构有助于随后包含新知识，室内污染物的其他化学类别，以及与室内人类暴露相关的额外机械过程。该框架可以作为开发开源界模型的基础，以更好地支持协作研究，并通过利益相关者改善申请的访问。结合使用该框架的曝光估计，使用该框架与不同端点的毒性数据和有毒机制将加速化学风险优先考虑，提前有效的化学管理决策，保护公共卫生。

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  • 来源
    《Environmental Science & Technology》 |2021年第1期|25-43|共19页
  • 作者

    Clara M. A. Eichler; Elaine A. Cohen Hubal; Ying Xu; Jianping Cao; Chenyang Bi; Charles J. Weschler; Tunga Salthammer; Glenn C. Morrison; Antti Joonas Koivisto; Yinping Zhang; Corinne Mandin; Wenjuan Wei; Patrice Blondeau; Dustin Poppendieck; Xiaoyu Liu; Christiaan J. E. Delmaar; Peter Fantke; Olivier Jolliet; Hyeong-Moo Shin; Miriam L. Diamond; Manabu Shiraiwa; Andreas Zuend; Philip K. Hopke; Natalie von Goetz; Markku Kulmala; John C. Little;

  • 作者单位

    Department of Civil and Environmental Engineering Virginia Tech Blacksburg Virginia 24060 United States Department of Environmental Sciences and Engineering Gillings School of Global Public Health The University of North Carolina at Chapel Hill Chapel Hill North Carolina 27599 United States;

    Office of Research and Development U.S. EPA Research Triangle Park North Carolina 27711 United States;

    Department of Building Science Tsinghua University Beijing 100084 China;

    School of Environmental Science and Engineering Sun Yat-sen University Guangzhou Guangdong 510006 China;

    Department of Civil and Environmental Engineering Virginia Tech Blacksburg Virginia 24060 United States;

    Environmental and Occupational Health Sciences Institute Rutgers University Piscataway New Jersey 08854 United States International Centre for Indoor Environment and Energy Department of Civil Engineering Technical University of Denmark hyngby 2800 Denmark;

    Fraunhofer WKI Department of Material Analysis and Indoor Chemistry Braunschweig 38108 Germany;

    Department of Environmental Sciences and Engineering Gillings School of Global Public Health The University of North Carolina at Chapel Hill Chapel Hill North Carolina 27599 United States;

    Institute for Atmospheric and Earth System Research (INAR) University of Helsinki Helsinki 00014 Finland;

    Department of Building Science Tsinghua University Beijing 100084 China;

    University of Paris-Est Scientific and Technical Center for Building (CSTB) French Indoor Air Quality Observatory (OQAI) Champs sur Marne 77447 France;

    University of Paris-Est Scientific and Technical Center for Building (CSTB) French Indoor Air Quality Observatory (OQAI) Champs sur Marne 77447 France;

    Laboratoire des Sciences de l'Ingenieur pour l'Environnement - LaSIE Universite de La Rochelle La Rachelle 77447 France;

    Engineering Lab National Institute of Standards and Technology Gaithersburg Maryland 20899 United States;

    Office of Research and Development U.S. EPA Research Triangle Park North Carolina 27711 United States;

    National Institute for Public Health and the Environment Center for Safety of Substances and Products Bilthoven 3720 The Netherlands;

    Quantitative Sustainability Assessment Department of Technology Management and Economics Technical University of Denmark Kgs. Lyngby 2800 Denmark;

    Department of Environmental Health Sciences School of Public Health University of Michigan Ann Arbor Michigan 48109 United States;

    Department of Earth and Environmental Sciences University of Texas at Arlington Arlington Texas 76019 United States;

    Department of Earth Sciences University of Toronto Toronto Ontario M5S 3B1 Canada;

    Department of Chemistry University of California Irvine California 92697 United States;

    Department of Atmospheric and Oceanic Sciences McGill University Montreal Quebec H3A0B9 Canada;

    Center for Air Resources Engineering and Science Clarkson University Potsdam New York 13699-5708 United States Department of Public Health Sciences University of Rochester School of Medicine and Dentistry Rochester New York 14642 United States;

    Federal Office of Public Health Berne 3003 Switzerland;

    Institute for Atmospheric and Earth System Research (INAR) University of Helsinki Helsinki 00014 Finland;

    Department of Civil and Environmental Engineering Virginia Tech Blacksburg Virginia 24060 United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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