...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Metallothioneins May Not Be Enough-The Role of Phytochelatins in Invertebrate Metal Detoxification
【24h】

Metallothioneins May Not Be Enough-The Role of Phytochelatins in Invertebrate Metal Detoxification

机译：金属硫蛋白可能还不够-植物螯合剂在无脊椎动物金属排毒中的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

How do animals respond to environmental pollution by potentially toxic elements (PTEs), and what detoxification pathways do they use? This is a key question, not only to understand the fundamental biological responses of animals in contaminated environments, but also to assess if these responses can have practical uses, for example as biomarkers of pollution. Metallothioneins have been especially widely studied in this context. Metallothioneins are small cysteine-rich proteins that strongly bind soft metal ions-indeed, they were originally incorrectly believed to be cadmium-requiring enzymes, as they sequester cadmium so readily from the environment. They have repeatedly been shown to be strongly metal-inducible in many different animal species, and there is ample evidence (again, in multiple species) that knocking out metallothioneins reduces tolerance to PTEs such as cadmium.
机译：动物如何通过潜在的有毒元素（PTE）应对环境污染，以及它们使用了哪些排毒途径？这是一个关键问题，不仅要了解受污染环境中动物的基本生物学反应，而且要评估这些反应是否具有实际用途，例如作为污染的生物标记。在这种情况下，对金属硫蛋白进行了特别广泛的研究。金属硫蛋白是富含半胱氨酸的小蛋白，实际上牢固地结合了软金属离子，最初被错误地认为是需要镉的酶，因为它们很容易从环境中吸收镉。反复证明它们在许多不同的动物物种中都具有较强的金属诱导性，并且有充分的证据（同样在多个物种中）证明敲除金属硫蛋白会降低对PTE（例如镉）的耐受性。

著录项

  • 来源
    《Environmental Science & Technology》 |2014年第2期|885-886|共2页
  • 作者

    Jacob G. Bundy; Peter Kille; Manuel Liebeke; David J. Spurgeon;

  • 作者单位

    Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, U.K.;

    Cardiff School of Biosciences, Cardiff University, Park Place, Cardiff CF10 3US, U.K.;

    Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, U.K.,Max Planck Institute for Marine Microbiology, Department of Symbiosis, 28359 Bremen, Germany;

    Centre for Ecology and Hydrology, Maclean Building, Benson Lane, Wallingford OX10 8BB, U.K.;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号