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首页> 外文期刊>Environmental Science & Technology >C & N Isotope Analysis of Diclofenac to Distinguish Oxidative and Reductive Transformation and to Track Commercial Products
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C & N Isotope Analysis of Diclofenac to Distinguish Oxidative and Reductive Transformation and to Track Commercial Products

机译：双氯芬酸的C＆N同位素分析，以区分氧化和还原转化并追踪商业产品

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摘要

Although diclofenac is frequently found in aquatic systems, its degradability in the environment remains imperfectly understood. On the one hand, evidence from concentration analysis alone is inconclusive if an unknown hydrology impedes a distinction between degradation and dilution. On the other hand, not all transformation products may be detectable. As a new approach, we therefore developed GC-IRMS (gas chromatography-isotope-ratio mass-spectrom- etry) analysis for carbon and nitrogen isotope measurements of diclofenac. The method uses a derivatization step that can be conducted either online or offline, for optimized throughput or sensitivity, respectively. In combination with on-column injection, the latter method enables determination of diclofenac isotope ratios down to the sub-μgL~(-1) range in environmental samples. Degradation in an aerobic sediment-water system showed strong nitrogen isotope fractionation (ε_N = -7.1‰), whereas reductive diclofenac dechlorination was associated with significant carbon isotope fractionation (ε_C = -2.0‰). Hence dual element isotope analysis bears potential not only to detect diclofenac degradation, but even to distinguish both transformation pathways in the environment In an explorative survey, analysis of commercial diclofenac products showed significant differences in carbon and nitrogen isotope ratios, demonstrating a further potential to track, and potentially even to authenticate, commercial production batches.
机译：尽管双氯芬酸经常在水生系统中发现，但其在环境中的可降解性仍然不完善。一方面，如果未知的水文学阻碍了降解和稀释之间的区别，仅凭浓度分析的证据尚无定论。另一方面，并​​非所有的转化产物都可以检测到。因此，作为一种新方法，我们开发了GC-IRMS（气相色谱-同位素比质谱）分析技术用于双氯芬酸的碳和氮同位素测量。该方法使用可以在线或离线进行的衍生步骤，分别用于优化吞吐量或灵敏度。结合柱上进样，后一种方法可以测定环境样品中低至亚μgL〜（-1）范围内的双氯芬酸同位素比率。好氧沉积物-水系统中的降解显示出强烈的氮同位素分馏（ε_N= -7.1‰），而还原性双氯芬酸脱氯与碳同位素分馏显着相关（ε_C= -2.0‰）。因此，双元素同位素分析不仅具有检测双氯芬酸降解的潜力，而且甚至可以区分环境中的两种转化途径。在一项探索性调查中，对商业双氯芬酸产品的分析表明碳和氮同位素比存在显着差异，这表明有进一步的追踪潜力，甚至可以验证商业生产批次。

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  • 来源
    《Environmental Science & Technology》 |2014年第4期|2312-2320|共9页
  • 作者

    Michael P. Maier; Simon De Corte; Sebastian Nitsche; Thomas Spaett; Nico Boon; Martin Eisner;

  • 作者单位

    Helmholtz Zentrum Muenchen, German Research Center, Institute of Groundwater Ecology, Ingolstaedter Landstrasse 1, Neuherberg D-85764, Germany;

    Ghent University, Laboratory of Microbial Ecology and Technology, Coupure Links 653, Ghent 9000, Belgium;

    Helmholtz Zentrum Muenchen, German Research Center, Institute of Groundwater Ecology, Ingolstaedter Landstrasse 1, Neuherberg D-85764, Germany;

    Helmholtz Zentrum Muenchen, German Research Center, Institute of Groundwater Ecology, Ingolstaedter Landstrasse 1, Neuherberg D-85764, Germany;

    Ghent University, Laboratory of Microbial Ecology and Technology, Coupure Links 653, Ghent 9000, Belgium;

    Helmholtz Zentrum Muenchen, German Research Center, Institute of Groundwater Ecology, Ingolstaedter Landstrasse 1, Neuherberg D-85764, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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