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首页> 外文期刊>Environmental Science & Technology >Development of an Enhanced Mechanistically Driven Mode of Action Classification Scheme for Adverse Effects on Environmental Species
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Development of an Enhanced Mechanistically Driven Mode of Action Classification Scheme for Adverse Effects on Environmental Species

机译：开发增强的机械驱动的动作分类方案模式，对环境物种的不利影响

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摘要

This study developed a novel classification scheme to assign chemicals to a verifiable mechanism of (eco-) toxicological action to allow for grouping, read-across, and in silico model generation. The new classification scheme unifies and extends existing schemes and has, at its heart, direct reference to molecular initiating events (MIEs) promoting adverse outcomes. The scheme is based on three broad domains of toxic action representing nonspecific toxicity (e.g., narcosis), reactive mechanisms (e.g., electrophilicity and free radical action), and specific mechanisms (e.g., associated with enzyme inhibition). The scheme is organized at three further levels of detail beyond broad domains to separate out the mechanistic group, specific mechanism, and the MIEs responsible. The novelty of this approach comes from the reference to taxonomic diversity within the classification, transparency, quality of supporting evidence relating to MIEs, and that it can be updated readily.
机译：该研究开发了一种新的分类方案，将化学品分配给核实机制（Eco-）毒理学作用，以允许分组，读取和硅模型生成。 新的分类方案统一并延长现有计划，并在其心脏上直接提及分子启动事件（MIE）促进不良结果。 该方案基于表示非特异性毒性（例如，麻醉），反应机制（例如，亲电性和自由基作用）的三个胃肠结构域，以及特定机制（例如，与酶抑制相关）。 该方案以超越域名的另外三个细节组织，以分离机械组，具体机制和负责的MIES。 这种方法的新颖性来自分类，透明度，支持与MIES的证据质量的分类多样性的参考，并且可以随时更新。

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  • 来源
    《Environmental Science & Technology》 |2021年第3期|1897-1907|共11页
  • 作者

    Maria Sapounidou; David J. Ebbrell; Mark A. Bonnell; Bruno Campos; James W. Firman; Steve Gutsell; Geoff Hodges; Jayne Roberts; Mark T. D. Cronin;

  • 作者单位

    School of Pharmacy and Bimolecular Sciences Liverpool John Moores University Liverpool L3 3AF U.K.;

    School of Pharmacy and Bimolecular Sciences Liverpool John Moores University Liverpool L3 3AF U.K.;

    Science and Risk Assessment Directorate Environment & Climate Change Canada Gatineau Quebec K1A 0H3 Canada;

    Safety and Environmental Assurance Centre Unilever Colworth Science Park Bedfordshire MK44 1LQ U.K.;

    School of Pharmacy and Bimolecular Sciences Liverpool John Moores University Liverpool L3 3AF U.K.;

    Safety and Environmental Assurance Centre Unilever Colworth Science Park Bedfordshire MK44 1LQ U.K.;

    Safety and Environmental Assurance Centre Unilever Colworth Science Park Bedfordshire MK44 1LQ U.K.;

    Safety and Environmental Assurance Centre Unilever Colworth Science Park Bedfordshire MK44 1LQ U.K.;

    School of Pharmacy and Bimolecular Sciences Liverpool John Moores University Liverpool L3 3AF U.K.;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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