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首页> 外文期刊>Environmental Science & Technology >A Population-Based Cohort Study of Respiratory Disease and Long-Term Exposure to Iron and Copper in Fine Particulate Air Pollution and Their Combined Impact on Reactive Oxygen Species Generation in Human Lungs
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A Population-Based Cohort Study of Respiratory Disease and Long-Term Exposure to Iron and Copper in Fine Particulate Air Pollution and Their Combined Impact on Reactive Oxygen Species Generation in Human Lungs

机译：一种基于人群的呼吸道疾病队列和长期暴露于细颗粒空气污染中的长期暴露及其对人肺中反应性氧物种的综合影响

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摘要

Metal components in fine particulate matter (PM_(2.5)) from nontailpipe emissions may play an important role in underlying the adverse respiratory effects of PM_(2.5). We investigated the associations between long-term exposure to iron (Fe) and copper (Cu) in PM_(2.5) and their combined impact on reactive oxygen species (ROS) generation in human lungs, and the incidence of asthma, chronic obstructive pulmonary disease (COPD), COPD mortality, pneumonia mortality, and respiratory mortality. We conducted a population-based cohort study of ～0.8 million adults in Toronto, Canada. Land-use regression models were used to estimate the concentrations of Fe, Cu, and ROS. Outcomes were ascertained using validated health administrative databases. We found positive associations between long-term exposure to Fe, Cu, and ROS and the risks of all five respiratory outcomes. The associations were more robust for COPD, pneumonia mortality, and respiratory mortality than for asthma incidence and COPD mortality. Stronger associations were observed for ROS than for either Fe or Cu. In two-pollutant models, adjustment for nitrogen dioxide somewhat attenuated the associations while adjustment for PM_(2.5) had little influence. Long-term exposure to Fe and Cu in PM_(2.5) and estimated ROS concentration in lung fluid was associated with increased incidence of respiratory diseases, suggesting the adverse respiratory effects of nontailpipe emissions.
机译：来自Nontailpipe排放的细颗粒物质（PM_（2.5））中的金属组分可能在潜在的PM_（2.5）的不良呼吸效果中起重要作用。我们调查了PM_（2.5）中长期暴露于铁（Fe）和铜（Cu）的关联，以及它们对人肺中的活性氧物种（ROS）产生的综合影响以及哮喘，慢性阻塞性肺病的发生率（COPD），COPD死亡率，肺炎死亡率和呼吸死亡率。我们在加拿大多伦多〜80万成人进行了一项基于人口的队列研究。土地使用回归模型用于估算Fe，Cu和ROS的浓度。使用经过验证的健康管理数据库确定结果。我们发现长期暴露于Fe，Cu和ROS之间的积极协会以及所有五种呼吸结果的风险。关联对于COPD，肺炎死亡率和呼吸死亡率比哮喘发病率和COPD死亡率更强。对于ROS而不是Fe或Cu，观察到更强的联合。在两种污染物模型中，氮素二氧化氮的调整有点衰减关联，同时调整PM_（2.5）影响很小。在PM_（2.5）中的Fe和Cu和肺液中的估计ROS浓度的长期暴露与呼吸系统疾病的发生率增加有关，表明Nontailpipe排放的不良呼吸效应。

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  • 来源
    《Environmental Science & Technology》 |2021年第6期|3807-3818|共12页
  • 作者

    Zilong Zhang; Scott Weichenthal; Jeffrey C. Kwong; Richard T. Burnett; Marianne Hatzopoulou; Michael Jerrett; Aaron van Donkelaar; Li Bai; Randall V. Martin; Ray Copes; Hong Lu; Pascale Lakey; Manabu Shiraiwa; Hong Chen;

  • 作者单位

    Public Health Ontario Toronto ON MSG 1V2 Canada ICES Toronto ON M4N 3MS Canada;

    Department of Epidemiology Biostatistics and Occupational Health McGill University Montreal QC H3A 0G4 Canada Air Health Science Division Health Canada Ottawa ON K1A 0K9 Canada;

    Public Health Ontario Toronto ON MSG 1V2 Canada ICES Toronto ON M4N 3M5 Canada Dalla Lana School of Public Health and Department of Family and Community Medicine University of Toronto Toronto ON MSS 1A1 Canada;

    Environmental Health Science and Research Bureau Health Canada Ottawa ON K1A 0K9 Canada;

    Department of Civil and Mineral Engineering University of Toronto Toronto ON ON MSS Canada;

    School of Public Health University of California Los Angeles Los Angeles California 90095 United States;

    Department of Physics and Atmospheric Science Dalhousie University Halifax NS B3H 4R2 Canada Department of Energy Environmental and Chemical Engineering Washington University in St. Louis St. Louis Missouri 63130 United States;

    ICES Toronto ON M4N 3MS Canada;

    Department of Physics and Atmospheric Science Dalhousie University Halifax NS B3H 4R2 Canada Department of Energy Environmental and Chemical Engineering Washington University in St. Louis St Louis Missouri 63130 United States Harvard-Smithsonian Centre for Astrophysics Cambridge Massachusetts 02138 United States;

    Public Health Ontario Toronto ON MSG 1V2 Canada Daila Lana School of Public Health University of Toronto Toronto ON M5S 1A1 Canada;

    ICES Toronto ON M4N 3MS Canada;

    Department of Chemistry University of California Irvine Irvine California 92697 United States;

    Department of Chemistry University of California Irvine Irvine California 92697 United States;

    Public Health Ontario Toronto ON MSG 1V2 Canada ICES Toronto ON M4N 3MS Canada Dalla Lana School of Public Health University of Toronto Toronto ON M5S 1A1 Canada Environmental Health Science and Research Bureau Health Canada Ottawa ON K1A 0K9 Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    fine particulate matter; iron; copper; reactive oxygen species; respiratory disease incidence and mortality;

    机译：细颗粒物质;铁;铜;反应性氧气;呼吸系统发病率和死亡率;

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