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首页> 外文期刊>Environmental Science & Technology >Reduced Ambient PM_(2.5) Was Associated with a Decreased Risk of Chronic Kidney Disease: A Longitudinal Cohort Study
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Reduced Ambient PM_(2.5) Was Associated with a Decreased Risk of Chronic Kidney Disease: A Longitudinal Cohort Study

机译：减少的环境PM_（2.5）与慢性肾病的风险降低有关：纵向队列研究

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摘要

Many countries have dedicated to the mitigation of air pollution in the past several decades. However, evidence of beneficial effects of air quality improvement on chronic kidney disease (CKD) remains limited. We thus investigated the effects of dynamic changes (including deterioration and improvement) in air quality on the incidence of CKD in a longitudinal study in Taiwan. During 2001-2016, this study recruited a total of 163,197 Taiwanese residents who received at least two standard physical examinations. The level of fine particle matter (PM_(2.5)) was estimated using a high-resolution (1 km~2) satellite-based spatio-temporal model. We defined changes of PM_(2.5) concentrations (ΔPM_(2.5)) as the difference between the two-year average measurements during follow-up and during the immediately preceding visit. The time-dependent Cox regression model was adopted to evaluate the relationships between ΔPM_(2.5) and the incidence of CKD after adjusting for a series of covariates. The concentrations of PM_(2.5) in Taiwan peaked around 2004 and began to decrease since 2005. We observed an approximate linear concentration-response relationship of ΔPM_(2.5) with CKD incidence. Every 5 μg/m~3 decrease in the ambient concentration of PM_(2.5) was associated with a 25% reduced risk of CKD development [hazard ratio (HR): 0.75; 95% CI: 0.73, 0.78], In conclusion, this study demonstrated that the improvement of PM_(2.5) air quality might be associated with a lower risk of CKD development. Our findings indicate that reducing air pollution may effectively prevent the development of CKD.
机译：许多国家致力于在过去几十年中减轻空气污染。然而，空气质量改善对慢性肾病（CKD）有益效果的证据仍然有限。因此，我们研究了动态变化（包括恶化和改善）在台湾纵向研究中CKD发病率的气体质量的影响。在2001 - 2016年期间，本研究招募了共有163,197台的台湾居民，该居民至少接受了至少两个标准的体检。使用高分辨率（1 km〜2）卫星的时空模型估计细颗粒物质（PM_（2.5））水平。我们定义了PM_（2.5）浓度的变化（ΔPM_（2.5）），作为两年平均测量在随访期间和立即访问期间的差异。采用时间依赖的COX回归模型来评估ΔPM_（2.5）与调整一系列协变量后CKD的发生率之间的关系。台湾PM_（2.5）的浓度达到2004年左右，自2005年开始逐渐减少。我们观察到ΔPM_（2.5）具有CKD发病率的近似线性浓度 - 响应关系。 PM_（2.5）的环境浓度下每5μg/ m〜3减少与CKD发育的风险降低25％有关[危险比（HR）：0.75;总之，95％CI：0.73,0.78]本研究表明，PM_（2.5）空气质量的改善可能与CKD发育的风险较低。我们的研究结果表明，减少空气污染可有效防止CKD的发展。

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  • 来源
    《Environmental Science & Technology》 |2021年第10期|6876-6883|共8页
  • 作者

    Yacong Bo; Jeffery Robert Brook; Changqing Lin; Ly-yun Chang; Cui Guo; Yiqian Zeng; Zengli Yu; Tony Tarn; Alexis K. H. Lau; Xiang Qian Lao;

  • 作者单位

    ]ockey Club School of Public Health and Primary Care The Chinese University of Hong Kong Kowloon 999077 Hong Kong China;

    University of Toronto Toronto Ontario M5T 1R4 Canada;

    Division of Environtnent and Sustainability and Department of Civil and Environmental Engineering The Hong Kong University of Science and Technology Kowloon 999077 Hong Kong China;

    Gratia Christian College Kowloon 999077 Hong Kong China Institute of Sociology Academia Sinica Taipei 11529 Taiwan;

    Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong Kowloon 999077 Hong Kong China;

    Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong Kowloon 999077 Hong Kong China;

    Department of Nutrition and Food Hygiene School of Public Health Zhengzhou University Zhengzhou 450000 China;

    Department of Sociology The Chinese University of Hong Kong Kowloon 999077 Hong Kong China;

    Division of Environment and Sustainability and Department of Civil and Environmental Engineering The Hong Kong University of Science and Technology Kowloon 999077 Hong Kong China;

    Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong Kowloon 999077 Hong Kong China Shenzhen Research Institute of The Chinese University of Hong Kong Shenzhen S18000 China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    particulate matter; air quality improvement; chronic kidney disease; Taiwan;

    机译：颗粒物质;空气质量改进;慢性肾病;台湾;

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