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Potential Environmental Health Risk Analysis of Neonicotinoids and a Synergist

机译：新烟碱蛋白和协同主义的潜在环境健康风险分析

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摘要

The extensive use of neonicotinoid pesticides has led to their widespread presence in the environment, resulting in considerable safety risks to the ecosystem and human health. In this study, we investigated the biotransformation behavior of a cocktail of multiple neonicotinoids and piperonyl butoxide (PBO) synergist in vivo and their potential environmental health risk. It was found that neonicotinoids with a cyano group, such as acetamiprid and thiacloprid, tended to accumulate in liver and spleen tissues, while others with nitro groups (imidacloprid, thiamethoxam, clothianidin, dinotefuran, and nitenpyram) were mostly excreted in urine. In the presence of the synergist PBO, the metabolism of neonicotinoids in vivo changed, mainly through the nitro reduction pathway, while a low abundance of related metabolites was observed in the conventional hydroxylation and demethylation metabolic pathways, due to inhibition of CYP450 enzymes by the synergist. Furthermore, DNA methylation damage in vivo was exacerbated by the induction of hydroxylamine metabolites formed in the intermediate process of neonicotinoid metabolism with the synergistic effect of PBO, which resulted in a higher level of the O~6-methyldeoxyguanosine (O~6-medG) biomarker in the liver. Therefore, during the comprehensive evaluation of pesticide environmental risks, attention should be paid not only to the co-exposure mode under real environmental conditions but also to the potential risks of intermediate metabolism and related intermediate metabolites. This study provides a referential strategy and theoretical support for the health risk assessment of co-exposure of chemicals.
机译：广泛使用Neonicotinoid农药导致了它们在环境中的广泛存在，导致生态系统和人类健康产生了相当大的安全风险。在这项研究中，我们研究了多种新烟碱蛋白和哌隆丁丁丁氧化物（PbO）协同作用的混合物的生物转化行为及其潜在的环境健康风险。发现具有氰基的新烟蛋白，例如acetamiprid和噻虫草，倾向于在肝脏和脾脏组织中积聚，而其他用硝基（咪酰啉代洛啉，噻嗪类蛋白剂，Dinotefuran和Nitenpyram）在尿液中大多排出。在存在增效性PBO的情况下，体内奈彻氏素的代谢改变，主要通过硝基还原途径，而在常规的羟基化和去甲基化代谢途径中观察到较低的相关代谢物，由于Synergist抑制Cyp450酶。此外，通过PBO的协同作用，通过在Neonicotinoid代谢中间过程中形成的羟胺代谢物的诱导诱导羟胺代谢物的DNA甲基化损伤加剧了PBO的协同作用，这导致较高水平的O〜6-甲基甲醛（O〜6-Medg）生物标志物在肝脏中。因此，在综合评估农药环境风险期间，应注意在真实环境条件下的共同暴露模式下，也应支付给中间代谢和相关中间代谢物的潜在风险。本研究规定了对化学物质共同暴露的健康风险评估的参考策略和理论支持。

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  • 来源
    《Environmental Science & Technology》 |2021年第11期|7541-7550|共10页
  • 作者

    Liwei Xu; Xinxin Xu; Lingling Guo; Zhongxing Wang; Xiaoling Wu; Hua Kuang; Chuanlai Xu;

  • 作者单位

    State Key Laboratory of Food Science and Technology and International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and Technology Jiangnan University Wuxi Jiangsu 214122 People's Republic of China Collaborative Innovation center of Food Safety and Quality Control in Jiangsu Province Jiangnan University Wuxi Jiangsu 214122 People's Republic of China;

    State Key Laboratory of Food Science and Technology and International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and Technology Jiangnan University Wuxi Jiangsu 214122 People's Republic of China Collaborative Innovation center of Food Safety and Quality Control in Jiangsu Province Jiangnan University Wuxi Jiangsu 214122 People's Republic of China;

    State Key Laboratory of Food Science and Technology and International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and Technology Jiangnan University Wuxi Jiangsu 214122 People's Republic of China Collaborative Innovation center of Food Safety and Quality Control in Jiangsu Province Jiangnan University Wuxi Jiangsu 214122 People's Republic of China;

    State Key Laboratory of Food Science and Technology and International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and Technology Jiangnan University Wuxi Jiangsu 214122 People's Republic of China Collaborative Innovation center of Food Safety and Quality Control in Jiangsu Province Jiangnan University Wuxi Jiangsu 214122 People's Republic of China;

    State Key Laboratory of Food Science and Technology and International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and Technology Jiangnan University Wuxi Jiangsu 214122 People's Republic of China Collaborative Innovation center of Food Safety and Quality Control in Jiangsu Province Jiangnan University Wuxi Jiangsu 214122 People's Republic of China;

    State Key Laboratory of Food Science and Technology and International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and Technology Jiangnan University Wuxi Jiangsu 214122 People's Republic of China Collaborative Innovation center of Food Safety and Quality Control in jiangsu Province Jiangnan University Wuxi Jiangsu 214122 People's Republic of China;

    State Key Laboratory of Food Science and Technology and International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and Technology Jiangnan University Wuxi Jiangsu 214122 People's Republic of China Collaborative Innovation center of Food Safety and Quality Control in Jiangsu Province Jiangnan University Wuxi Jiangsu 214122 People's Republic of China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    environmental health risk; neonicotinoids; co-exposure; metabolite; pesticides synergist;

    机译：环境健康风险;neonicotinoids;共同曝光;代谢物;杀虫剂协同作者;

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