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首页> 外文期刊>Environmental Science & Technology >Comparative in Vitro Toxicity of Nitrosamines and Nitramines Associated with Amine-based Carbon Capture and Storage
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Comparative in Vitro Toxicity of Nitrosamines and Nitramines Associated with Amine-based Carbon Capture and Storage

机译：亚硝胺和硝胺与基于胺的碳捕获和储存相关的体外毒性比较

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摘要

Amine-based CO_2 capture is a prime contender for the first full-scale implementation of CO_2 capture at fossil fuel-fired power plants postcombustion. However, the formation of potentially carcinogenic N-nitrosamines and N-nitramines from reactions of flue gas NO_x with the amines presents a potential risk for contaminating airsheds and drinking water supplies. Setting regulatory emission limits is hampered by the dearth of taxicity information for the N-nitramines. This study employed quantitative in vitro bioassays for mutagenicity in Salmonella typhimurium, and chronic cytotoxicity and acute genotoxicity in Chinese hamster ovary (CHO) cells to compare the toxicity of analogous N-nitrosamines and N-nitramines relevant to CO_2 capture. Although the rank order was similar for genotoxicity in CHO cells and mutageniciry in S. typhimurium, the Solmonella assay was far more sensitive. In general, mutagenicity was higher with S9 hepatic microsoman activation. The rank order of mutagenicity was N-nitrosodimethylamine (NDMA) ＞ N-nitrosomorpholine ＞ N-nitrodimethylamine ＞1,4-dinitrosopiperazine ＞ N-nitromorpholine ＞1,4-dinitropiperazine ＞ N-nitromonoethanolamine ＞ N-nitrosodiethanolamine ＞ N-nitrodiethanolamine. 1-Nitrosopiperazine and 1-nitropiperazine were not mutagenic. Overall, N-nitrosamines were ～15-fold more mutagenic than their N-nitramine analogues.
机译：基于胺的CO_2捕集是燃烧后化石燃料发电厂首次全面实施CO_2捕集的主要竞争者。但是，烟道气NO_x与胺的反应形成可能致癌的N-亚硝胺和N-硝胺，存在污染空域和饮用水的潜在风险。缺乏N-硝胺的出租车信息限制了法规排放限值的设置。这项研究采用了定量的体外生物测定方法来分析鼠伤寒沙门氏菌的致突变性，以及中国仓鼠卵巢（CHO）细胞的慢性细胞毒性和急性基因毒性，以比较与CO_2捕获有关的类似N-亚硝胺和N-硝胺的毒性。尽管在CHO细胞中的遗传毒性和鼠伤寒沙门氏菌的致突变性的等级顺序相似，但Solmonella分析的灵敏度要高得多。通常，随着S9肝微粒体激活，致突变性更高。致突变性的等级顺序是N-亚硝基二甲胺（NDMA）＞ N-亚硝基吗啉＞ N-硝基二甲胺＞ 1,4-二硝基哌嗪＞ N-亚硝基吗啉＞ 1,4-二硝基哌嗪＞ N-硝基单乙醇胺＞ N-硝基二乙醇胺＞ N-硝基二乙醇胺。 1-硝基哌嗪和1-硝基哌嗪不致突变。总体而言，N-亚硝胺的致突变性是其N-硝胺类似物的15倍。

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  • 来源
    《Environmental Science & Technology》 |2014年第14期|8203-8211|共9页
  • 作者

    Elizabeth D. Wagner; Jennifer Osiol; William A. Mitch; Michael J. Plewa;

  • 作者单位

    Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States,Center for Advanced Materials for the Purification of Water with Systems, and the Global Safe Water Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States;

    Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States;

    Department of Civil and Environmental Engineering, Stanford University, Stanford, California 94305, United States;

    Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States,Center for Advanced Materials for the Purification of Water with Systems, and the Global Safe Water Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States,University of Illinois, 364 NSRC, 1101 West Peabody Drive, Urbana, IL 61801, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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