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首页> 外文期刊>Environmental Science & Technology >Bioaccumulation and Toxicity of CuO Nanoparticles by a Freshwater Invertebrate after Waterborne and Dietborne Exposures
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Bioaccumulation and Toxicity of CuO Nanoparticles by a Freshwater Invertebrate after Waterborne and Dietborne Exposures

机译：暴露于水和饮食中的淡水无脊椎动物对CuO纳米颗粒的生物累积和毒性

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摘要

The incidental ingestion of engineered nanoparticles (NPs) can be an important route of uptake for aquatic organisms. Yet, knowledge of dietary bioavailability and toxicity of NPs is scarce. Here we used isotopically modified copper oxide (~(65)CuO) NPs to characterize the processes governing their bioaccumulation in a freshwater snail after waterborne and dietborne exposures. Lymnaca stagnalis efficiently accumulated ~(65)Cu after aqueous and dietary exposures to ~(65)CuO NPs. Cu assimilation efficiency and feeding rates averaged 83% and 0.61 g g~(-1) d~(-1) at low exposure concentrations (＜100 nmol g~(-1)), and declined by nearly 50% above this concentration. We estimated that 80-90% of the bioaccumulated ~(65)Cu concentration in L. stagnalis originated from the ~(65)CuO NPs, suggesting that dissolution had a negligible influence on Cu uptake from the NPs under our experimental conditions. The physiological loss of ~(65)Cu incorporated into tissues after exposures to ~(65)CuO NPs was rapid over the first days of depuration and not detectable thereafter. As a result, large Cu body concentrations are expected in L stagnalis after exposure to CuO NPs. To the degree that there is a link between bioaccumulation and toxicity, dietborne exposures to CuO NPs are likely to elicit adverse effects more readily than waterborne exposures.
机译：工程纳米颗粒（NPs）的偶然摄入可能是水生生物吸收的重要途径。然而，关于NPs的饮食生物利用度和毒性的知识很少。在这里，我们使用同位素修饰的氧化铜（〜（65）CuO）NPs表征了在水和饮食中暴露后在淡水蜗牛中控制其生物蓄积的过程。在水和饮食中暴露于〜（65）CuO NPs后，香蒲可以有效地积累〜（65）Cu。在低暴露浓度（＜100 nmol g〜（-1））下，铜的同化效率和进料速率平均为83％和0.61 g g〜（-1）d〜（-1），比该浓度下降近50％。我们估计，葡萄球菌的〜（65）Cu生物累积浓度的80-90％来自〜（65）CuO NP，这表明在我们的实验条件下，溶出对NP吸收Cu的影响可以忽略不计。暴露于〜（65）CuO NP后掺入组织的〜（65）Cu的生理损失在净化的最初几天迅速，此后无法检测到。结果，暴露于CuO NPs后的胸骨中预计会有较大的Cu体浓度。从某种程度上讲，生物蓄积性和毒性之间存在联系，与水传播相比，饮食中暴露于CuO NPs可能更容易引起不良反应。

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  • 来源
    《Environmental Science & Technology》 |2014年第18期|10929-10937|共9页
  • 作者

    Marie-Noele Croteau; Superb K. Misra; Samuel N. Luoma; Eugenia Valsami-Jones;

  • 作者单位

    U.S. Geological Survey, Menlo Park, California 94025, United States;

    School of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom;

    U.S. Geological Survey, Menlo Park, California 94025, United States,John Muir Institute of the Environment, University of California, Davis, California 95616, United States;

    School of Geography, Earth and Environmental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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