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首页> 外文期刊>Environmental Science & Technology >Appalachian Mountaintop Mining Particulate Matter Induces Neoplastic Transformation of Human Bronchial Epithelial Cells and Promotes Tumor Formation
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Appalachian Mountaintop Mining Particulate Matter Induces Neoplastic Transformation of Human Bronchial Epithelial Cells and Promotes Tumor Formation

机译：阿巴拉契亚山顶开采的颗粒物诱导人支气管上皮细胞的肿瘤转化并促进肿瘤形成

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摘要

Epidemiological studies suggest that living near mountaintop coal mining (MTM) activities is one of the contributing factors for high lung cancer incidence. The purpose of this study was to investigate the long-term carcinogenic potential of MTM particulate matter (PM_(MTM)) exposure on human bronchial epithelial cells. Our results show that chronic exposure (3 months) to noncytotoxic, physiological relevant concentration (1 μg/mL) of PM_(MTM), but not control particle PM_(CON) induced neoplastic transformation, accelerated cell proliferation, and enhanced cell migration of the exposed lung cells. Xenograft transplantation of the PM_(MTM)-exposed cells in mice caused no apparent tumor formation, but promoted tumor growth of human lung carcinoma H460 cells, suggesting the tumor-promoting effect of PM_(MTM). Chronic exposure to the main inorganic chemical constituent of PM_(MTM), molybdenum but not silica, similarly induced cell transformation and tumor promotion, suggesting the contribution of molybdenum, at least in part, in the PM_(MTM) effects. These results provide new evidence for the carcinogenic potential of PM_(MTM) and support further risk assessment and implementation of exposure control for PM_(MTM).
机译：流行病学研究表明，住在山顶煤矿（MTM）附近的活动是导致肺癌高发的因素之一。这项研究的目的是调查人类支气管上皮细胞上MTM颗粒物（PM_（MTM））暴露的长期致癌潜力。我们的结果表明，长期暴露（3个月）暴露于无细胞毒性的生理相关浓度（1μg/ mL）的PM_（MTM），但未控制颗粒PM_（CON）诱导肿瘤转化，加速细胞增殖并增强了细胞的迁移暴露的肺细胞。暴露于PM_（MTM）的小鼠的异种移植未引起明显的肿瘤形成，但促进了人肺癌H460细胞的肿瘤生长，提示PM_（MTM）具有促肿瘤作用。长期暴露于PM_（MTM）的主要无机化学成分中，钼而不是二氧化硅，同样会诱导细胞转化和促进肿瘤，提示钼至少部分地在PM_（MTM）效应中起作用。这些结果为PM_（MTM）的致癌潜力提供了新证据，并支持进一步的风险评估和PM_（MTM）暴露控制的实施。

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  • 来源
    《Environmental Science & Technology》 |2014年第21期|12912-12919|共8页
  • 作者

    Sudjit Luanpitpong; Michael Chen; Travis Knuckles; Sijin Wen; Juhua Luo; Emily Ellis; Michael Hendryx; Yon Rojanasakul;

  • 作者单位

    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, United States,Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, United States,Siriraj Center of Excellence for Stem Cell Research, Mahidol University, Bangkok 10700, Thailand;

    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, United States,Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, United States;

    Center for Cardiovascular and Respiratory Science, West Virginia University, Morgantown, West Virginia 26506, United States;

    Department of Biostatistics, West Virginia University, Morgantown, West Virginia 26506, United States;

    School of Public Health, Indiana University, Bloomington, Indiana 47405, United States;

    Animal Models and Imaging Facility, West Virginia University, Morgantown, West Virginia 26506, United States;

    School of Public Health, Indiana University, Bloomington, Indiana 47405, United States;

    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, United States,Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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