...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Disruption of Oxidative Phosphorylation (OXPHOS) by Hydroxylated Polybrominated Diphenyl Ethers (OH-PBDEs) Present in the Marine Environment
【24h】

Disruption of Oxidative Phosphorylation (OXPHOS) by Hydroxylated Polybrominated Diphenyl Ethers (OH-PBDEs) Present in the Marine Environment

机译：海洋环境中存在的羟基化多溴联苯醚（OH-PBDEs）破坏氧化磷酸化（OXPHOS）

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) are of growing concern, as they have been detected in both humans and wildlife and have been shown to be toxic. Recent studies have indicated that OH-PBDEs can be more toxic than PBDEs, partly due to their ability to disrupt oxidative phosphorylation (OXPHOS), an essential process in energy metabolism. In this study, we determined the OXPHOS disruption potential of 18 OH-PBDE congeners reported in marine wildlife using two in vitro bioassays, namely the classic rat mitochondrial respiration assay, and a mitochrondrial membrane potential assay using zebrafish PAC2 cells. Single OH-PBDE congeners as well as mixtures were tested to study potential additive or synergistic effects. An environmental mixture composed of seven OH-PBDE congeners mimicking the concentrations reported in Baltic blue mussels were also studied. We report that all OH-PBDEs tested were able to disrupt OXPHOS via either protonophoric uncoupling and/ or inhibition of the electron transport chain. Additionally we show that OH-PBDEs tested in combinations as found in the environment have the potential to disrupt OXPHOS. Importantly, mixtures of OH-PBDEs may show very strong synergistic effects, stressing the importance of further research on the in vivo impacts of these compounds in the environment.
机译：羟基化的多溴联苯醚（OH-PBDEs）受到越来越多的关注，因为它们已在人类和野生动植物中被检测到并被证明具有毒性。最近的研究表明，OH-PBDEs的毒性比PBDEs高，部分原因是它们具有破坏能量代谢必不可少的氧化磷酸化（OXPHOS）的能力。在这项研究中，我们使用两种体外生物测定法，即经典的大鼠线粒体呼吸测定法和使用斑马鱼PAC2细胞的线粒体膜电位测定法，确定了海洋野生动物中报告的18种OH-PBDE同系物的OXPHOS破坏潜力。测试了单个OH-PBDE同系物及其混合物，以研究潜在的加性或协同效应。还研究了由7种OH-PBDE同类物组成的环境混合物，该混合物模仿了波罗的海贻贝中报道的浓度。我们报告所有测试的OH-PBDEs能够通过质子解偶联和/或抑制电子传输链来破坏OXPHOS。此外，我们还表明，在环境中发现结合测试的OH-PBDEs有可能破坏OXPHOS。重要的是，OH-PBDEs的混合物可能表现出非常强的协同作用，从而强调了进一步研究这些化合物对环境的体内影响的重要性。

著录项

  • 来源
    《Environmental Science & Technology》 |2014年第24期|14703-14711|共9页
  • 作者

    Jessica Legradi; Anna-Karin Dahlberg; Peter Cenijn; Goeran Marsh; Lillemor Asplund; Ake Bergman; Juliette Legler;

  • 作者单位

    Institute for Environmental Studies, VU University Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands;

    Environmental Chemistry Unit, Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden;

    Institute for Environmental Studies, VU University Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands;

    Environmental Chemistry Unit, Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden;

    Environmental Chemistry Unit, Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden;

    Environmental Chemistry Unit, Department of Materials and Environmental Chemistry, Stockholm University, SE-106 91 Stockholm, Sweden;

    Institute for Environmental Studies, VU University Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号