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首页> 外文期刊>Environmental Science & Technology >The Anti-Inflammatory Drugs Diclofenac, Naproxen and Ibuprofen are found in the Bile of Wild Fish Caught Downstream of a Wastewater Treatment Plant
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The Anti-Inflammatory Drugs Diclofenac, Naproxen and Ibuprofen are found in the Bile of Wild Fish Caught Downstream of a Wastewater Treatment Plant

机译：在废水处理厂下游捕获的野生鱼的胆汁中发现了抗炎药双氯芬酸，萘普生和布洛芬

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摘要

Pharmaceutical residues are ubiquitous in rivers, lakes, and at coastal waters affected by discharges from municipal wastewater treatment plants. In this study, the presence of 17 different pharmaceutical and six different phase I metabolites was determined in the bile of two wild fish species, bream (Abramis brama) and roach (Rutilus rutilus). The fish were caught from a lake that receives treated municipal wastewater via a small river. Prior to analyses, the bile content was enzymatically hydrolyzed to convert the glucuronide metabolites into the original pharmaceuticals or phase I metabolites. The solid phase extracts of hydrolyzates were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the multiple reaction monitoring mode. The anti-inflammatory drug naproxen could be detected in all the six bream and roach bile samples. Didofenac was found in five of the bream and roach samples, while ibuprofen was detected in three bream and two roach samples. The observed bile concentrations of didofenac, naproxen, and ibuprofen in bream ranged from 6 to 95 ng mL~(-1), 6 to 32 ng mL~(-1), and 16 to 34 ng mL~(-1), respectively. The corresponding values in roach samples ranged from 44 to 148 ng mL~(-1), 11 to 103 ng mL~(-1) and 15 to 26 ng mL~(-1), respectively. None of the other studied compounds could be detected. The study shows that pharmaceuticals originating from wastewater treatment plant effluents can be traced to the bile of wild bream and roach living in a lake where didofenac, naproxen, and ibuprofen are present as pollutants.
机译：受城市废水处理厂排放影响的河流，湖泊和沿海水域普遍存在药物残留。在这项研究中，确定了两种野生鱼类（（Abramis brama）和蟑螂（Rutilus rut​​ilus））的胆汁中存在17种不同的药物和6种不同的I期代谢物。鱼是从一个湖泊中捕获的，该湖泊通过一条小河接收处理过的市政废水。在分析之前，将胆汁含量进行酶水解以将葡糖醛酸苷代谢物转化为原始药物或I相代谢物。通过液相色谱-串联质谱（LC-MS / MS）在多反应监测模式下分析水解产物的固相提取物。可以在所有六个鲷鱼和蟑螂胆汁样品中检测到抗炎药萘普生。在五个five和蟑螂样品中发现了地芬非那，而在三个和两个蟑螂样品中发现了布洛芬。观察到的中的双氧芬酸，萘普生和布洛芬的胆汁浓度分别为6至95 ng mL〜（-1），6至32 ng mL〜（-1）和16至34 ng mL〜（-1）。 。蟑螂样品中的相应值分别为44至148 ng mL〜（-1），11至103 ng mL〜（-1）和15至26 ng mL〜（-1）。其他研究的化合物均无法检测到。该研究表明，源自废水处理厂废水的药物可追溯到生活在湖泊中的野鲷和蟑螂的胆汁，那里的双氧芬酸，萘普生和布洛芬是污染物。

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  • 来源
    《Environmental Science & Technology》 |2013年第1期|342-348|共7页
  • 作者

    Jenny-Maria Brozinski; Marja Lahti; Axel Meierjohann; Aimo Oikari; Leif Kronberg;

  • 作者单位

    Laboratory of Organic Chemistry, Abo Akademi University, Biskopsgatan 8, FI-20500 ABO, Finland;

    Department of Biological and Environmental Sciences, University of Jyvaeskylae, FI-40014 University of Jyvaskyla, Finland;

    Laboratory of Organic Chemistry, Abo Akademi University, Biskopsgatan 8, FI-20500 ABO, Finland;

    Department of Biological and Environmental Sciences, University of Jyvaeskylae, FI-40014 University of Jyvaskyla, Finland;

    Laboratory of Organic Chemistry, Abo Akademi University, Biskopsgatan 8, FI-20500 ABO, Finland;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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