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首页> 外文期刊>Environmental Science & Technology >Reactive Oxygen Species Alteration of Immune Cells in Local Residents at an Electronic Waste Recycling Site in Northern China
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Reactive Oxygen Species Alteration of Immune Cells in Local Residents at an Electronic Waste Recycling Site in Northern China

机译：中国北方电子废物回收站当地居民免疫细胞的活性氧形态变化

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摘要

The health effects of exposure to pollutants from electronic waste (e-waste) pose an important issue. In this study, we explored the association between oxidative stress and blood levels of e-waste-related pollutants. Blood samples were collected from individuals living in the proximity of an e- waste recycling site located in northern China, and pollutants, as well as reactive oxygen species (ROS), were measured in comparison to a reference population. The geometric mean concentrations of PCBs, dechlorane plus, and 2,2',4,4',5,5'- hexabromobiphenyl in plasma from the exposure group were 60.4, 9.0, and 0.55 ng g~(-1) lipid, respectively, which were 2.2, 3.2, and 2.2 times higher than the corresponding measurement in the reference group. Correspondingly, ROS levels in white blood cells, including in neutrophil granulocytes, from the exposure group were significantly higher than in those from the reference group, suggesting potential ROS related health effects for residents at the e-waste site. In contrast, fewer ROS were generated in the respiratory burst of neutrophil granulocytes for the exposure group, indicating a depressed innate immune function for the individuals living at the e-waste site. These findings suggest a potential linkage between exposure to pollutants from e-waste recycling and both elevated oxidative stress and altered immune function.
机译：暴露于电子废物（电子废物）中的污染物对健康的影响是一个重要问题。在这项研究中，我们探讨了氧化应激与电子废物相关污染物的血液水平之间的关系。从居住在中国北方电子废物回收站附近的个体采集血样，并与参考人群进行比较，测量污染物和活性氧（ROS）。暴露组血浆中PCBs，十氯烷和2,2'，4,4'，5,5'-六溴代二苯的几何平均浓度分别为60.4、9.0和0.55 ng g〜（-1）脂质，分别是参考组中相应测量值的2.2倍，3.2倍和2.2倍。相应地，接触组的白细胞（包括嗜中性粒细胞）中的ROS水平显着高于参考组，这表明电子垃圾场所居民可能存在与ROS相关的健康影响。相反，接触组在嗜中性粒细胞的呼吸爆发中产生的ROS较少，这表明生活在电子废物场所的个体的先天免疫功能下降。这些发现表明，暴露于电子废物回收中的污染物与氧化应激升高和免疫功能改变之间存在潜在的联系。

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  • 来源
    《Environmental Science & Technology》 |2013年第7期|3344-3352|共9页
  • 作者

    Ran Li; Qjaoyun Yang; Xinghua Qiu; Keqiu Li; Guang Li; Ping Zhu; Tong Zhu;

  • 作者单位

    State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering and Center for Environment and Health, Peking University, Beijing 100871, P. R. China;

    State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering and Center for Environment and Health, Peking University, Beijing 100871, P. R. China;

    College of Environmental Sciences and Engineering, Peking University, Beijing 100871,P. R. China ,State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering and Center for Environment and Health, Peking University, Beijing 100871, P. R. China;

    Basic Medical College, Tianjin Medical University, Tianjin 300070, P. R. China;

    College of Environmental Sciences and Engineering, Peking University, Beijing 100871,P. R. China ,Basic Medical College, Tianjin Medical University, Tianjin 300070, P. R. China;

    Department of Hematology, Peking University First Hospital, Beijing 100034, P. R. China;

    State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering and Center for Environment and Health, Peking University, Beijing 100871, P. R. China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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