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Hydroxylated Polybrominated Diphenyl Ethers in Paired Maternal and Cord Sera

机译：配对的母体和脐带血清中的羟基化多溴联苯醚

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摘要

Polybrominated diphenyl ethers (PBDEs) were widely used as flame retardants in the past three decades. These compounds are lipophilic and easily cross the placenta from pregnant woman to fetus. It is not clear whether hydroxylated PBDEs (OH-PBDEs), with greater hydro- philicity, have different concentrations in maternal and cord serum samples. We analyzed PBDEs (BDE-28, -47, -99, -100, -153, -154, -209) and OH-PBDEs (6-OH-BDE-47, 5-OH- BDE-47, 4'-OH-BDE-49, 5'-OH-BDE-99) in 20 pairs of maternal and cord serum samples collected in Cincinnati, OH in 2011. The geometric mean concentration of ∑OH- BDEs (the sum of four OH-PBDEs) was 49.76 pg/mL in cord sera, higher than 32.84 pg/mL in maternal sera. Similarly, cord serum total BDEs had a higher geometric mean than maternal serum (45-51 vs 32.07 ng/g lipid). Equal or higher levels of total OH-BDEs and total BDEs in cord serum were observed in 85% and 80% of the mother-neonate pairs, respectively. The study suggests fetuses might receive higher OH-PBDE and PBDE exposure than their mothers.
机译：在过去的三十年中，多溴二苯醚（PBDEs）被广泛用作阻燃剂。这些化合物具有亲脂性，容易从孕妇到胎儿穿过胎盘。尚不清楚具有较高亲水性的羟基化多溴二苯醚（OH-PBDEs）在母体和脐带血清样品中是否具有不同的浓度。我们分析了PBDEs（BDE-28，-47，-99，-100，-153，-154，-209）和OH-PBDEs（6-OH-BDE-47、5-OH- BDE-47、4'- 2011年在俄亥俄州辛辛那提采集的20对产妇和脐带血清样本中的OH-BDE-49、5'-OH-BDE-99）。∑OH- BDEs的几何平均浓度（四种OH-PBDEs的总和）脐带血中的血脂为49.76 pg / mL，高于母体血中的32.84 pg / mL。同样，脐带血清总BDEs的几何平均值高于母体血清（45-51 vs 32.07 ng / g脂质）。在脐带血清中，分别有85％和80％的脐带血中总OH-BDEs和总BDEs水平相等或更高。研究表明，胎儿可能比其母亲接受更高的OH-PBDE和PBDE暴露。

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  • 来源
    《Environmental Science & Technology》 |2013年第8期|3902-3908|共7页
  • 作者

    Aimin Chen; June-Soo Park; Linda Linderholm; Alexandra Rhee; Myrto Petreas; Emily A DeFranco; Kim N. Dietrich; Shuk-mei Ho;

  • 作者单位

    Division of Epidemiology and Biostatistics, Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States ,Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati College of Medicine, P.O. Box 670056, Cincinnati, OH 45267-0056, USA;

    Environmental Chemistry Laboratory, California Department of Toxic Substances Control, California Environmental Protection , Agency, Berkeley, California, United States;

    Environmental Chemistry Laboratory, California Department of Toxic Substances Control, California Environmental Protection , Agency, Berkeley, California, United States;

    Environmental Chemistry Laboratory, California Department of Toxic Substances Control, California Environmental Protection , Agency, Berkeley, California, United States;

    Environmental Chemistry Laboratory, California Department of Toxic Substances Control, California Environmental Protection , Agency, Berkeley, California, United States;

    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States;

    Division of Epidemiology and Biostatistics, Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States;

    Division of Epidemiology and Biostatistics, Department of Environmental Health, Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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