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首页> 外文期刊>Environmental Science & Technology >Cellular Internalization of Dissolved Cobalt ions from Ingested CoFe_2O_4 Nanoparticles: In Vivo Experimental Evidence
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Cellular Internalization of Dissolved Cobalt ions from Ingested CoFe_2O_4 Nanoparticles: In Vivo Experimental Evidence

机译：从摄入的CoFe_2O_4纳米颗粒中溶解的钴离子的细胞内在化：体内实验证据。

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摘要

With a model invertebrate animal, we have assessed the fate of magnetic nanoparticles in biologically relevant media, Le., digestive juices. The toxic potential and the internalization of such nanoparticles by nontarget cells were also examined. The aim of this study was to provide experimental evidence on the formation of Co_(2+), Fe_(2+), and Fe_(3+) ions from CoFe_2O_4 nanoparticles in the digestive juices of a model organism. Standard toxicological parameters were assessed. Cell membrane stability was tested with a modified method for measurement of its quality. Proton-induced X-ray emission and low energy synchrotron radiation X-ray fluorescence were used to study internalization and distribution of Co and Fe. Co_(2+) ions were found to be more toxic than nanoparticles. We confirmed that Co_(2+) ions accumulate in the hepatopancreas, but Fe_(n+) ions or CoFe_2O_4 nanoparticles are not retained in vivo. A model biological system with a terrestrial isopod is suited to studies of the potential dissolution of ions and other products from metal-containing nanoparticles in biologically complex media.
机译：对于无脊椎动物的模型，我们评估了生物学相关介质（例如消化液）中磁性纳米颗粒的命运。还检查了非靶细胞对此类纳米颗粒的毒性和内在作用。这项研究的目的是为模型生物的消化液中CoFe_2O_4纳米粒子形成Co_（2 +），Fe_（2+）和Fe_（3+）离子提供实验证据。评估标准毒理学参数。用改进的方法测试细胞膜的稳定性，以测量其质量。质子诱导的X射线发射和低能同步辐射X射线荧光用于研究Co和Fe的内在化和分布。发现Co_（2+）离子比纳米颗粒更具毒性。我们证实，Co_（2+）离子积累在肝胰腺中，但Fe_（n +）离子或CoFe_2O_4纳米颗粒没有保留在体内。具有陆生等足类动物的模型生物系统适用于研究离子和其他产物从含金属的纳米颗粒在生物复杂介质中的潜在溶解。

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  • 来源
    《Environmental Science & Technology》 |2013年第10期|5400-5408|共9页
  • 作者

    Sara Novak; Damjana Drobne; Miha Golobic; Jernej Zupanc; Tea Romih; Alessandra Gianoncelli; Maya Kiskinova; Burkhard Kaulich; Primoz Pelicon; Primoz Vavpetic; Luka Jeromel; Nina Ogrinc; Darko Makovec;

  • 作者单位

    Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia;

    Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia,Centre of Excellence, Advanced Materials and Technologies for the Future (CO NAMASTE), Jamova cesta 39, 1000 Ljubljana, Slovenia,Center of Exelence, Nanoscience and Nanotechnology (Nanocentre), Jamova cesta 39, 1000 Ljubljana, Slovenia;

    Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia;

    Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia;

    Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, 1000 Ljubljana, Slovenia;

    Elettra-Sinchrotrone Trieste S.C.p.A., Strada Statale 14-km 163.5 in AREA Science Park, 34149 Basovizza, Trieste, Italy;

    Elettra-Sinchrotrone Trieste S.C.p.A., Strada Statale 14-km 163.5 in AREA Science Park, 34149 Basovizza, Trieste, Italy;

    Elettra-Sinchrotrone Trieste S.C.p.A., Strada Statale 14-km 163.5 in AREA Science Park, 34149 Basovizza, Trieste, Italy;

    Jozef Stefan Institute, Microanalytical Center, Department for Low and Medium Energy Physics, Jamova cesta 39, 1000 Ljubljana, Slovenia;

    Jozef Stefan Institute, Microanalytical Center, Department for Low and Medium Energy Physics, Jamova cesta 39, 1000 Ljubljana, Slovenia;

    Jozef Stefan Institute, Microanalytical Center, Department for Low and Medium Energy Physics, Jamova cesta 39, 1000 Ljubljana, Slovenia;

    Jozef Stefan Institute, Microanalytical Center, Department for Low and Medium Energy Physics, Jamova cesta 39, 1000 Ljubljana, Slovenia,LOTRIC Metrology, Selca 163, 4227 Selca, Slovenia;

    Institute Jozef Stefan, Jamova cesta 39, 1000 Ljubljana, Slovenia;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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