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首页> 外文期刊>Environmental Science & Technology >Effect of Bisphenol A on Rat Metabolic Profiling Studied by Using Capillary Electrophoresis Time-of-Flight Mass Spectrometry
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Effect of Bisphenol A on Rat Metabolic Profiling Studied by Using Capillary Electrophoresis Time-of-Flight Mass Spectrometry

机译：毛细管电泳飞行时间质谱法研究双酚A对大鼠代谢谱的影响

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摘要

Bisphenol A (BPA), a chemical widely used in the manufacture of polycarbonate plastics, has raised considerable concern in recent decades because of its hormone-like properties. Whether BPA exposure is a health -risk remains controversial in many countries. A metabolomics study based on capillary electrophoresis time-of-flight mass spectrometry (CE-TOF/MS) was performed to study the urine metabolic profiles of Sprague-Dawley rats fed with four dose levels of BPA (0, 1, 10, and 100 μg/kg body weight) for 45 days. Multivariate pattern recognition directly reflected the metabolic perturbations caused by BPA. On the basis of univariate analysis, 42 metabolites including amino acids, polyamines, nucleosides, organic acids, carbohydrates, pterins, polyphenols, and sugar phosphates were found as the most significantly differential metabolites. The marked perturbations were related with valine, leucine and isoleucine biosynthesis, d-glutamine and d-glutamate metabolism, etc. Significant alterations of neurotransmitters (ghitamate, gamma-aminobutyric acid, and noradrenaline) and neurotransmitter-related metabolites (tyrosine, histamine, valine, and taurine) suggested that the toxic effects of small-dose BPA (below 50 mg/kg/day) may contribute to its interactions with the neuromediating system. Our study demonstrated that metabolomics may offer more specific insights into the molecular changes underlying the physiological effects of BPA.
机译：双酚A（BPA）是一种广泛用于制造聚碳酸酯塑料的化学物质，由于其类似激素的性质，最近几十年来引起了人们的广泛关注。在许多国家，双酚A暴露是否是健康风险仍存在争议。进行了基于毛细管电泳飞行时间质谱（CE-TOF / MS）的代谢组学研究，研究了以四种剂量水平的BPA（0、1、10和100喂养）喂养的Sprague-Dawley大鼠的尿液代谢特征微克/千克体重）持续45天。多元模式识别直接反映了BPA引起的代谢紊乱。根据单变量分析，发现42种代谢物是最明显的差异代谢物，其中包括氨基酸，多胺，核苷，有机酸，碳水化合物，蝶呤，多酚和糖磷酸酯。明显的扰动与缬氨酸，亮氨酸和异亮氨酸的生物合成，d-谷氨酰胺和d-谷氨酸的代谢有关。和牛磺酸）表明小剂量BPA（低于50 mg / kg /天）的毒性作用可能有助于其与神经介导系统的相互作用。我们的研究表明，代谢组学可能会对BPA生理效应的分子变化提供更具体的见解。

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  • 来源
    《Environmental Science & Technology》 |2013年第13期|7457-7465|共9页
  • 作者

    Jun Zeng; Hua Kuang; Chunxiu Hu; Xianzhe Shi; Min Yan; Liguang Xu; Libing Wang; Chuanlai Xu; Guowang Xu;

  • 作者单位

    CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;

    School of Food Science & Technology and State Key Lab of Food Science & Technology, Jiangnan University, Wuxi Jiangsu, 214122, China;

    CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;

    CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;

    CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;

    School of Food Science & Technology and State Key Lab of Food Science & Technology, Jiangnan University, Wuxi Jiangsu, 214122, China;

    School of Food Science & Technology and State Key Lab of Food Science & Technology, Jiangnan University, Wuxi Jiangsu, 214122, China;

    School of Food Science & Technology and State Key Lab of Food Science & Technology, Jiangnan University, Wuxi Jiangsu, 214122, China;

    CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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