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首页> 外文期刊>Environmental Science & Technology >Molecular Mechanisms of Toxicity of Silver Nanoparticles in Zebrafish Embryos
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Molecular Mechanisms of Toxicity of Silver Nanoparticles in Zebrafish Embryos

机译：斑马鱼胚胎中银纳米颗粒毒性的分子机制

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摘要

Silver nanoparticles cause toxicity in exposed organisms and are an environmental health concern. The mechanisms of silver nanoparticle toxicity, however, remain unclear. We examined the effects of exposure to silver in nano-, bulk-, and ionic forms on zebrafish embryos (Danio rerio) using a Next Generation Sequencing approach in an Illumina platform (High-Throughput SuperSAGE). Significant alterations in gene expression were found for all treatments and many of the gene pathways affected, most notably those associated with oxidative phosphorylation and protein synthesis, overlapped strongly between the three treatments indicating similar mechanisms of toxicity for the three forms of silver studied. Changes in oxidative phosphorylation indicated a down-regulation of this pathway at 24 h of exposure, but with a recovery at 48 h. This finding was consistent with a dose-dependent decrease in oxygen consumption at 24 h, but not at 48 h, following exposure to silver ions. Overall, our data provide support for the hypothesis that the toxicity caused by silver nanoparticles is principally associated with bioavailable silver ions in exposed zebrafish embryos. These findings are important in the evaluation of the risk that silver particles may pose to exposed vertebrate organisms.
机译：银纳米颗粒在暴露的生物体中会引起毒性，是对环境健康的关注。然而，银纳米颗粒毒性的机制仍不清楚。我们使用Illumina平台中的下一代测序方法（高通量SuperSAGE），研究了纳米，本体和离子形式的银暴露对斑马鱼胚胎（Danio rerio）的影响。在所有处理中均发现了基因表达的显着改变，并且受影响的许多基因途径，最显着的是与氧化磷酸化和蛋白质合成相关的途径，在三种处理之间强烈重叠，表明研究的三种形式的银具有相似的毒性机制。氧化磷酸化的变化表明该途径在暴露后24小时下调，但在48小时后恢复。这一发现与暴露于银离子后24小时（而非48小时）的耗氧量呈剂量依赖性降低是一致的。总体而言，我们的数据为以下假设提供了支持：由银纳米颗粒引起的毒性主要与暴露的斑马鱼胚胎中的生物利用性银离子有关。这些发现对于评估银颗粒可能对暴露的脊椎动物造成的风险非常重要。

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  • 来源
    《Environmental Science & Technology》 |2013年第14期|8005-8014|共10页
  • 作者

    Ronny van Aerie; Anke Lange; Alex Moorhouse; Konrad Paszkiewicz; Katie Ball; Blair D. Johnston; Eliane de-Bastos; Timothy Booth; Charles R. Tyler; Eduarda M. Santos;

  • 作者单位

    Biosciences, College of Life and Environmental Sciences, Geoffrey Pope Building, University of Exeter, Stocker Road, Exeter, EX4 4QD, U.K.;

    Biosciences, College of Life and Environmental Sciences, Geoffrey Pope Building, University of Exeter, Stocker Road, Exeter, EX4 4QD, U.K.;

    Biosciences, College of Life and Environmental Sciences, Geoffrey Pope Building, University of Exeter, Stocker Road, Exeter, EX4 4QD, U.K.;

    Biosciences, College of Life and Environmental Sciences, Geoffrey Pope Building, University of Exeter, Stocker Road, Exeter, EX4 4QD, U.K.;

    Biosciences, College of Life and Environmental Sciences, Geoffrey Pope Building, University of Exeter, Stocker Road, Exeter, EX4 4QD, U.K.;

    Biosciences, College of Life and Environmental Sciences, Geoffrey Pope Building, University of Exeter, Stocker Road, Exeter, EX4 4QD, U.K.;

    Biosciences, College of Life and Environmental Sciences, Geoffrey Pope Building, University of Exeter, Stocker Road, Exeter, EX4 4QD, U.K.;

    NBAF-W, Centre for Ecology & Hydrology (CEH) Wallingford, Benson Lane, Wallingford, OX10 8BB, U.K.;

    Biosciences, College of Life and Environmental Sciences, Geoffrey Pope Building, University of Exeter, Stocker Road, Exeter, EX4 4QD, U.K,Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum Muenchen, Ingol-staedter Landstr. 1, 85764 Neuherberg, Germany;

    Biosciences, College of Life and Environmental Sciences, Geoffrey Pope Building, University of Exeter, Stocker Road, Exeter, EX4 4QD, U.K,Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum Muenchen, Ingol-staedter Landstr. 1, 85764 Neuherberg, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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