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首页> 外文期刊>Environmental Science & Technology >In-Stream Attenuation of Neuro-Active Pharmaceuticals and Their Metabolites
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In-Stream Attenuation of Neuro-Active Pharmaceuticals and Their Metabolites

机译：神经活性药物及其代谢产物的流内衰减

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摘要

In-stream attenuation was determined for 14 neuro-active pharmaceut-icals and associated metabolites. Lagrangian sampling, which follows a parcel of water as it moves downstream, was used to link hydrological and chemical transformation processes. Wastewater loading of neuro-active compounds varied considerably over a span of several hours, and thus a sampling regime was used to verify that the Lagrangian parcel was being sampled and a mechanism was developed to correct measured concentrations if it was not. In-stream attenuation over the 5.4-km evaluated reach could be modeled as pseudo-first-order decay for 11 of the 14 evaluated neuro-active pharmaceutical compounds, illustrating the capacity of streams to reduce conveyance of neuro-active compounds downstream. Fluoxetine and N-desmethyl citalopram were the most rapidly attenuated compounds (t_(1/2) = 3.6 ± 0.3 h, 4.0 ± 0.2 h, respectively). Lamotrigine, 10,11,-dihydro-10,ll,-dihydroxy-carbamazepine, and carbamazepine were the most persistent (t_(1/2) - 12 ± 2.0 h, 12 ± 2.6 h, 21 ± 4.5 h, respectively). Parent compounds (e.g., buproprion, carbamazepine, lamotrigine) generally were more persistent relative to their metabolites. Several compounds (citalopram, venlafaxine, O-desmethyl-venlafaxine) were not attenuated. It was postulated that the primary mechanism of removal for these compounds was interaction with bed sediments and stream biofilms, based on measured concentrations in stream biofilms and a column experiment using stream sediments.
机译：确定了14种神经活性药物和相关代谢产物的入流衰减。拉格朗日采样随水流向下游移动时被用来链接水文和化学转化过程。神经活性化合物的废水负荷在几个小时的跨度内变化很大，因此使用了一种采样方案来验证是否对拉格朗日包裹进行了采样，并且开发了一种机制来校正未测量的浓度。可以将在5.4公里评估范围内的流内衰减建模为14种评估神经活性药物中的11种的伪一级衰减，从而说明水流减少下游神经活性化合物输送的能力。氟西汀和N-去甲基西酞普兰是衰减最快的化合物（t_（1/2）= 3.6±0.3 h，4.0±0.2 h）。拉莫三嗪，10,11，-dihydro-10，ll，-dihydroxy-carbamazepine和carbamazepine是最持久的（t_（1/2）-12±2.0 h，12±2.6 h，21±4.5 h）。母体化合物（例如，安非他酮，卡马西平，拉莫三嗪）相对于它们的代谢物通常更具持久性。几种化合物（西酞普兰，文拉法辛，O-去甲基文拉法辛）没有减弱。据推测，去除这些化合物的主要机理是基于测得的河流生物膜浓度和使用河流沉积物的柱实验，与床沉积物和河流生物膜相互作用。

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  • 来源
    《Environmental Science & Technology》 |2013年第17期|9781-9790|共10页
  • 作者

    Jeffrey H. Writer; Ronald C. Antweiler; Imma Ferrer; Joseph N. Ryan; E. Michael Thurman;

  • 作者单位

    Department of Civil, Environmental, and Architectural Engineering, University of Colorado, 428 UCB, Boulder, Colorado 80309-0428, United States,U.S. Geological Survey, 3215 Marine Street, Boulder, Colorado 80303, United States;

    U.S. Geological Survey, 3215 Marine Street, Boulder, Colorado 80303, United States;

    Department of Civil, Environmental, and Architectural Engineering, University of Colorado, 428 UCB, Boulder, Colorado 80309-0428, United States;

    Department of Civil, Environmental, and Architectural Engineering, University of Colorado, 428 UCB, Boulder, Colorado 80309-0428, United States;

    Department of Civil, Environmental, and Architectural Engineering, University of Colorado, 428 UCB, Boulder, Colorado 80309-0428, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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