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首页> 外文期刊>Environmental Science & Technology >Temporal Changes of Urinary Oxidative Metabolites of Di(2-ethylhexyl)phthalate After the 2011 Phthalate Incident in Taiwanese Children: Findings of a Six Month Follow-Up
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Temporal Changes of Urinary Oxidative Metabolites of Di(2-ethylhexyl)phthalate After the 2011 Phthalate Incident in Taiwanese Children: Findings of a Six Month Follow-Up

机译:台湾儿童2011年邻苯二甲酸酯事件后邻苯二甲酸二(2-乙基己基)酯的尿氧化代谢产物的时间变化:六个月的随访结果。

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摘要

A major incident involving phthalates-contaminated foodstuffs occurred in Taiwan in May 2011,leading to the quick removal of tainted food items from store shelves.We investigated changes in urinary oxidative di(2-ethylhexyl)phthalate (DEHP) metabolites,our proxy for exposure to DEHP-tainted foodstuffs in children ≤10 years,during the six months following withdrawal of the tainted food.Our hospital screened 60 possibly exposed children between May and June 2011.The children's food intake information was collected,and they were administered one-spot urine samples at baseline and at the two and six month follow-ups.All three samples were measured for four oxidative DEHP metabolites,mono-(2-ethyl-5-hydroxyhexyl) phthalate (SOH-MEHP),mono-(2-ethyl-5-oxohexyl) phthalate (Soxo-MEHP),mono-(2-ethyl-5-carboxypentyl) phthalate (5cx-MEPP),and mono-(2-carboxyme-thylhexyl) phthalate (2cx-MMHP) by triple quadrupole liquid chromatography tandem mass spectrometry.Fifty-two children had been exposed.After excluding those without a fall set of urine samples or adequate food intake information,23 exposed children were studied.We found significantly positive correlations between DEHP daily intake and urinary 50H-MEHP,Soxo-MEHP,and Scx-MEPP (p < 0.05).At the six month follow-up,all four metabolite concentrations had significantly decreased compared to the baseline.In conclusion,urinary DEHP metabolites decreased progressively in children after tainted food withdrawal,indicating that the main sources of phthalate contamination for children had been successfully controlled.
机译:2011年5月,台湾发生了一起涉及邻苯二甲酸盐污染的食品的重大事件,导致迅速从货架上清除了受污染的食品。我们调查了尿氧化性邻苯二甲酸二(2-乙基己基)酯(DEHP)代谢产物的变化,该物质是我们的接触代理在撤回被污染食物后的六个月内,对DEHP≤10岁的儿童进行食物污染。我们医院对2011年5月至2011年6月之间可能暴露的60名儿童进行了筛查。收集了儿童的食物摄入信息,并一站式进行管理在基线以及两个月和六个月的随访中采集尿液样品。对这三个样品进行了测定,测定了四种氧化性DEHP代谢产物,邻苯二甲酸单-(2-乙基-5-羟基己基)酯(SOH-MEHP),单-(2-乙基三重四极杆液体通过邻苯二甲酸-5-氧己基)邻苯二甲酸酯(Soxo-MEHP),单(2-乙基-5-羧基戊基)邻苯二甲酸酯(5cx-MEPP)和邻苯二甲酸单(2-羧甲基-乙基己基)邻苯二甲酸酯(2cx-MMHP)色谱串联质谱法。有52名儿童被暴露。除没有尿液样本量下降或没有足够食物摄入信息的儿童外,我们对23名暴露儿童进行了研究。我们发现DEHP日摄入量与尿50H-MEHP,Soxo-MEHP和Scx-MEPP之间呈显着正相关(p <0.05)在六个月的随访中,与基线相比,所有四种代谢物的浓度均显着降低。总之,戒断食物后儿童的尿中DEHP代谢物逐渐减少,表明儿童的邻苯二甲酸盐污染的主要来源已得到成功控制。 。

著录项

  • 来源
    《Environmental Science & Technology》 |2013年第23期|13754-13762|共9页
  • 作者单位

    Department of Public Health,College of Health Sciences,Kaohsiung Medical University,Room 721,CS Building,No.100,Shih-Chuan First Road,Kaohsiung 807,Taiwan;

    Department of Laboratory Medicine,Kaohsiung Me&cal University Hospital,No.100,Shih-Chuan First Road,Kaohsiung 807,Taiwan,Department of Pediatrics,Kaohsiung Medical University Hospital,Kaohsiung Medical University,No.100,Shih-Chuan First Road,Kaohsiung 807,Taiwan;

    Department of Chemistry,National Sun Yat-Sen University,No.70,Lienhai Road,Kaohsiung 804,Taiwan;

    Center for General Education,Kaohsiung Medical University,No.100,Shih-Chuan First Road,Kaohsiung 807,Taiwan;

    Department of Neurology,Kaohsiung Medical University Hospital,No.100,Shih-Chuan First Road,Kaohsiung 807,Taiwan;

    Department of Pediatrics,Kaohsiung Medical University Hospital,Kaohsiung Medical University,No.100,Shih-Chuan First Road,Kaohsiung 807,Taiwan;

    Department of Public Health,College of Health Sciences,Kaohsiung Medical University,Room 721,CS Building,No.100,Shih-Chuan First Road,Kaohsiung 807,Taiwan;

    Department of Pediatrics,Kaohsiung Medical University Hospital,Kaohsiung Medical University,No.100,Shih-Chuan First Road,Kaohsiung 807,Taiwan;

    Department of Public Health,College of Health Sciences,Kaohsiung Medical University,Room 721,CS Building,No.100,Shih-Chuan First Road,Kaohsiung 807,Taiwan,Department of Family Medicine,Kaohsiung Medical University Hospital,Kaohsiung Medical University,No.100,Shih-Chuan First Road,Kaohsiung 807,Taiwan,Center of Environmental and Occupational Medicine,Kaohsiung Municipal Hsiao-Kang Hospital,Kaohsiung Medical University,No.482,Shanming Road,Kaohsiung 812,Taiwan;

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  • 原文格式 PDF
  • 正文语种 eng
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