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首页> 外文期刊>Environmental Science & Technology >Bisphenol A and Its Chlorinated Derivatives in Human Colostrum
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Bisphenol A and Its Chlorinated Derivatives in Human Colostrum

机译：人初乳中的双酚A及其氯化衍生物

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摘要

The health effects related to bisphenol A (BPA) and its exposure sources have undergone extensive investigation,but no consensus has been reached.Hitherto,the major source of human BPA exposure considered in the literature remains food-contact material.However,the chlorine present in drinking water may react with BPA to form chlorinated derivatives (Cl_xBPA),which have indeed been shown to have a heightened level of estrogenic activity.In this study,we have evaluated colostrum concentrations of BPA and Cl_xBPA in order to confirm our hypothesis according to which BPA water contamination leads to Cl_xBPA human exposure.BPA and its Cl_xBPA were assessed through online solid-phase extraction coupled to ultra high-performance liquid chromatography tandem mass spectrometry (SPE-UPLC-MS/MS) using the isotope dilution method in the colostrums of 21 women who had completed a water exposure questionnaire.BPA was detected in 19 colostrums and its Cl_xBPA in 21 colostrums.Mean concentrations were 1.87 ± 1.38 ng mL~(-1) (n = 19) for BPA,1.87 ± 1.23 ng mL~(-1) (n = 7) and 1.56 ± 0.74 (n = 18) ng mL~(-1) for 2,2'-Cl_2BPA and 2,6-Cl_2BPA,respectively,and 0.68 ng mL~(-1) (n = 1) for trichloro-BPA.These findings confirm our hypothesis that Cl_xBPA should be taken into account in human health risk assessment.
机译：与双酚A（BPA）及其暴露源有关的健康影响已得到广泛研究，但尚未达成共识。迄今为止，文献中所考虑的人类BPA暴露的主要来源仍为食物接触材料。在饮用水中可能会与BPA反应形成氯化衍生物（Cl_xBPA），其确实显示出较高的雌激素活性。在这项研究中，我们评估了BPA和Cl_xBPA的初乳浓度，以根据确定我们的假设。通过在线固相萃取结合超高效液相色谱串联质谱法（SPE-UPLC-MS / MS）在初乳中使用同位素稀释法对BPA及其Cl_xBPA进行了评估21位完成了水暴露调查问卷的女性中，在19份初乳中检测到BPA，在21份初乳中检测到Cl_xBPA。 BPA为1.87±1.38 ng mL〜（-1）（n = 19），BPA为1.87±1.23 ng mL〜（-1）（n = 7）和1.56±0.74（n = 18）ng mL〜（-1） 2,2'-Cl_2BPA和2,6-Cl_2BPA分别为三氯-BPA 0.68 ng mL〜（-1）（n = 1）。这些发现证实了我们的假设，即在人类健康风险中应考虑Cl_xBPA评定。

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  • 来源
    《Environmental Science & Technology》 |2013年第23期|13791-13797|共7页
  • 作者

    Virginie Migeot; Antoine Dupuis; Axelle Cariot; Marion Albouy-Llaty; Fabrice Pierre; Sylvie Rabouan;

  • 作者单位

    University of Poitiers,UMR-CNRS 7285 (IC2MP) School of Medicine and Pharmacy (Departments of Analytical Chemistry,Pharmaceutics and Epidemiology),Poitiers,France,Biology-Pharmacy-Public Health Department,University Hospital of Poitiers,Poitiers,France;

    University of Poitiers,UMR-CNRS 7285 (IC2MP) School of Medicine and Pharmacy (Departments of Analytical Chemistry,Pharmaceutics and Epidemiology),Poitiers,France,Biology-Pharmacy-Public Health Department,University Hospital of Poitiers,Poitiers,France;

    University of Poitiers,UMR-CNRS 7285 (IC2MP) School of Medicine and Pharmacy (Departments of Analytical Chemistry,Pharmaceutics and Epidemiology),Poitiers,France,Biology-Pharmacy-Public Health Department,University Hospital of Poitiers,Poitiers,France;

    University of Poitiers,UMR-CNRS 7285 (IC2MP) School of Medicine and Pharmacy (Departments of Analytical Chemistry,Pharmaceutics and Epidemiology),Poitiers,France,Biology-Pharmacy-Public Health Department,University Hospital of Poitiers,Poitiers,France;

    Woman-Mother-Child Department,University Hospital of Poitiers,Poitiers,France;

    University of Poitiers,UMR-CNRS 7285 (IC2MP) School of Medicine and Pharmacy (Departments of Analytical Chemistry,Pharmaceutics and Epidemiology),Poitiers,France;

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