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首页> 外文期刊>Environmental Science & Technology >Microbial Inactivation by Cupric Ion in Combination with H_2O_2: Role of Reactive Oxidants
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Microbial Inactivation by Cupric Ion in Combination with H_2O_2: Role of Reactive Oxidants

机译：铜离子与H_2O_2结合对微生物的灭活作用：活性氧化剂的作用

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摘要

The cupric ion mediated inactivation of Escherichia coli was enhanced by the presence of hydrogen peroxide (H_2O_2),with increasing inactivation efficacy observed in response to increasing concentrations of H_2O_2.The biocidal activity of the Cu(Ⅱ)/H_2O_2 system is believed to result from the oxidative stress caused by reactive oxidants such as the hydroxyl radical (~·OH),cupryl species (Cu(Ⅲ)),and the superoxide radical (O_2~(·-)),which are produced via the catalytic decomposition of H_2O_2.In E.coli cells treated with Cu(Ⅱ) and H_2O_2,the intracellular level of ~·OH and Cu(Ⅲ) increased significantly,leading to complete disruption of cell membranes.On the basis of experimental observations made using an ~·OH scavenger,copper-chelating agents,and superoxide dismutase,it is concluded that Cu(Ⅲ) is the predominant species responsible for the death of E.coli cells.It was also found that the production of Cu(Ⅲ) was promoted by the reactions of copper with intracellular O_2~(·-).MS2 coliphage was found to be even more susceptible than E.coli to the oxidative stress induced by the Cu(Ⅱ)/H_2O_2 system.
机译：过氧化氢（H_2O_2）的存在促进了铜离子介导的大肠杆菌的失活，随着H_2O_2浓度的增加，灭活效果也增强。据认为，Cu（Ⅱ）/ H_2O_2系统的杀生物活性是由于氢氧自由基（〜·OH），铜离子（Cu（Ⅲ），超氧自由基（O_2〜（·-））等活性氧化剂通过H_2O_2的催化分解而产生的氧化应力。在用Cu（Ⅱ）和H_2O_2处理的大肠杆菌细胞中，〜·OH和Cu（Ⅲ）的细胞内水平显着增加，导致细胞膜完全破坏。基于〜·OH清除剂的实验观察，铜螯合剂和超氧化物歧化酶的结论是，Cu（Ⅲ）是导致大肠杆菌细胞死亡的主要原因。同时发现，Cu（Ⅲ）的产生是由铜的反应促进的。铜与细胞内O_2〜（·-）。MS2大肠杆菌发现ge比大肠杆菌更容易受到Cu（Ⅱ）/ H_2O_2系统诱导的氧化应激的影响。

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  • 来源
    《Environmental Science & Technology》 |2013年第23期|13661-13667|共7页
  • 作者

    Thuy T.M.Nguyen; Hee-Jin Park; Jee Yeon Kim; Hyung-Eun Kim; Hongshin Lee; Jeyong Yoon; Changha Lee;

  • 作者单位

    School of Urban and Environmental Engineering,Ulsan National Institute of Science and Technology (UNIST),100 Banyeon-ri,Eonyang-eup,Ulju-gun,Ulsan 698-805,Republic of Korea;

    School of Chemical and Biological Engineering,College of Engineering,Institute of Chemical Process,Seoul National University (SNU),Daehak-dong,Gwanak-gu,Seoul 151-744,Republic of Korea;

    DMC R&D center,Samsung Electronics Co.,129 Samsung-ro,Yeongtong-gu,Suwon-si,Gyeonggi-do 443-742,Republic of Korea;

    School of Urban and Environmental Engineering,Ulsan National Institute of Science and Technology (UNIST),100 Banyeon-ri,Eonyang-eup,Ulju-gun,Ulsan 698-805,Republic of Korea;

    School of Urban and Environmental Engineering,Ulsan National Institute of Science and Technology (UNIST),100 Banyeon-ri,Eonyang-eup,Ulju-gun,Ulsan 698-805,Republic of Korea;

    School of Chemical and Biological Engineering,College of Engineering,Institute of Chemical Process,Seoul National University (SNU),Daehak-dong,Gwanak-gu,Seoul 151-744,Republic of Korea;

    School of Urban and Environmental Engineering,Ulsan National Institute of Science and Technology (UNIST),100 Banyeon-ri,Eonyang-eup,Ulju-gun,Ulsan 698-805,Republic of Korea;

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