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首页> 外文期刊>Environmental Science & Technology >Urinary Amino-Polycyclic Aromatic Hydrocarbons in Urban Residents: Finding a Biomarker for Residential Exposure to Diesel Traffic
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Urinary Amino-Polycyclic Aromatic Hydrocarbons in Urban Residents: Finding a Biomarker for Residential Exposure to Diesel Traffic

机译：城市居民中尿氨基 - 多环芳烃：寻找柴油交通的住宅暴露生物标志物

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摘要

Despite substantial evidence of marked exposure to and ill-health effects from diesel exhaust (DE) emissions among occupational population (e.g., miners, truck drivers, and taxi drivers), it is less understood to what extent non-occupational population was exposed to DE among various combustion sources, largely due to the lack of biomarkers that would indicate specific exposure to DE. We evaluated whether urinary amino-polycyclic aromatic hydrocarbons (APAHs), such as major metabolites of DE-specific nitrated PAHs, can be used as DE exposure biomarkers in residential settings. We measured five urinary APAHs in 177 urine samples from 98 UK residents, 89 (91%) of them were London residents, and estimated their residential proximity to various traffic indicators (e.g., the road type, road length, traffic flow, and traffic volume). Participants living within 100 m of major roads exhibited increased levels of all five APAHs, among which 2-amino-fluorene (2-AFLU) reached statistical significance (p ＜ 0.05). We estimated that a 10 m increase in the length of nearby major roads (＜100 m) was associated with a 4.4% (95% CI of 1.1 to 7.6%) increase in 2-AFLU levels. Levels of 2-AFLU were significantly associated with the traffic flow of nearby buses and heavy-duty vehicles but not motorbikes, taxis, or coaches. We did not observe a significant association between distance to major roads or the sum of the major road length within 100 m with the other four biomarker concentrations. These results suggest the use of urinary 2-AFLU as a biomarker of DE exposure in urban residents.
机译：尽管职业人口（例如矿工，卡车司机和出租车司机的柴油排放（DE）排放的明显有明显的证据证明了柴油机（DE）排放，但在职业职业人口暴露于DE的程度上，仍然不太了解在各种燃烧源中，主要是由于缺乏指示DE的特定暴露的生物标志物。我们评估了尿液氨基 - 多环芳烃（APAH），例如特异性硝化PAHs的主要代谢物，可用作住宅环境中的脱麸虫生物标志物。我们从98名英国居民的177名尿液样本中测量了五个尿APAH，其中89名（91％）是伦敦居民，并估计他们对各种交通指标的住宅邻近（例如，道路类型，道路长，交通流量和交通量）。生活在100米的主要道路范围内的参与者表现出所有五个APAH的水平增加，其中2-氨基芴（2-AFLU）达到统计学意义（P <0.05）。我们估计，附近的主要道路（<100米）的长度增加10米，与4.4％（95％CI为1.1％）增加2-艾鲁级。 2-AFLU的水平与附近公共汽车和重型车辆的交通流量显着相关，但不是摩托车，出租车或教练。我们没有观察到主要道路之间的距离之间的重大关联或在100米范围内的主要道路长度与另外四个生物标志物浓度。这些结果表明使用尿2-AFLU作为城市居民在城市居民中的生物标志物。

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  • 来源
    《Environmental Science & Technology》 |2021年第15期|10569-10577|共9页
  • 作者

    Zhenchun Yang; Yan Lin; Stella Wang; Xing Liu; Paul Cullinan; Kian Fan Chung; Junfeng Zhang;

  • 作者单位

    Global Health Research Center Duke Kunshan University Kunshan Jiangsu Province 215316 China;

    Nicholas School of the Environment and Global Health Institute Duke University Durham North Carolina 27708 United States;

    Nicholas School of the Environment and Global Health Institute Duke University Durham North Carolina 27708 United States;

    Nicholas School of the Environment and Global Health Institute Duke University Durham North Carolina 27708 United States;

    National Heart & Lung Institute Imperial College London London SW7 2AZ U.K.;

    National Heart & Lung Institute Imperial College London London SW7 2AZ U.K.;

    Global Health Research Center Duke Kunshan University Kunshan Jiangsu Province 215316 China Nicholas School of the Environment and Global Health Institute Duke University Durham North Carolina 27708 United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    air pollution; environmental exposure; heavy traffic; nitro-PAHs; diesel vehicles;

    机译：空气污染;环境暴露;交通繁忙;Nitro-Pahs;柴油车;

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