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首页> 外文期刊>Environmental Science & Technology >Organic Components of Personal PM_(2.5) Exposure Associated with Inflammation: Evidence from an Untargeted Exposomic Approach
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Organic Components of Personal PM_(2.5) Exposure Associated with Inflammation: Evidence from an Untargeted Exposomic Approach

机译：与炎症有关的个人PM_（2.5）接触的有机成分：来自无明确的爆发方法的证据

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摘要

Fine particulate matter (PM_(2.5)) can promote chronic diseases through the fundamental mechanism of inflammation; however, systemic information is lacking on the inflammatory PM_(2.5) components. To decipher organic components from personal PM_(2.5) exposure that were associated with respiratory and circulatory inflammatory responses in older adults, we developed an exposomic approach using trace amounts of particles and applied it on 424 personal PM_(2.5) samples collected in a panel study in Beijing. Applying an integrated multivariate and univariate untargeted strategy, a total of 267 organic compounds were filtered and then chemically identified according to their association with exhaled nitric oxide (eNO)/interleukin (lL)-6 or serum IL-1β/IL- 6, with monocyclic and polycyclic aromatic compounds (i.e., MACs and PACs) as the representatives. Indoor-derived species with medium volatility including MACs were mainly associated with systemic inflammation, while low-volatile ambient components that originate from combustion sources, such as PACs, were mostly associated with airway inflammation. Following ambient component exposure, we found an inverted U-shaped relationship on change of eNO with insulin resistance, suggesting a higher risk of cardiopulmonary dysfunction for individuals with homeostatic model assessment for insulin resistance (HOMA-IR) levels ＞ 2.3. Overall, this study provided a practical untargeted strategy for the systemic investigation of PM_(2.5) components and proposed source-specific inflammatory effects.
机译：细颗粒物质（PM_（2.5））可以通过炎症的基本机制来促进慢性疾病;但是，缺乏系统信息缺乏炎症PM_（2.5）组件。从个人PM_（2.5）的接触中破译有机组分，所述接触与老年人的呼吸和循环炎症反应相关，我们使用痕量的颗粒开发了一种拓展方法，并在小组研究中收集的424个个人PM_（2.5）样品上施加它在北京。施用整合多变量和单变量的未明确的策略，过滤总共267个有机化合物，然后根据其与呼出的一氧化氮（EnO）/白细胞介素（LL）-6或血清IL-1β/ IL-6进行化学鉴定，用单环和多环芳烃（即，Mac和PAC）作为代表。含有MAC的中等挥发性的室内衍生物种主要与全身炎症有关，而源自燃烧源的低挥发性环境成分大多与气道炎症相关。在环境分量暴露之后，我们发现了一种倒置的U形关系，就胰岛素抗性的eno变化，表明胰岛素抵抗（HOMA-IR）水平的具有稳态模型评估的个体心肺功能障碍的风险较高。总体而言，本研究为PM_（2.5）组分的全身调查提供了实际未明确的策略，以及提出的源特异性炎症效应。

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  • 来源
    《Environmental Science & Technology》 |2021年第15期|10589-10596|共8页
  • 作者

    Xing Jiang; Yiqun Han; Xinghua Qiu; Qianqian Chai; Hanxiyue Zhang; Xi Chen; Zhen Cheng; Yanwen Wang; Yunfei Fan; Tao Xue; Weiju Li; Jicheng Gong; Tong Zhu;

  • 作者单位

    State Key Joint Laboratory for Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and Health Peking University Beijing 100871 P. R. China;

    State Key Joint Laboratory for Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and Health Peking University Beijing 100871 P. R. China Environmental Research Group MRC Centre for Environment and Health imperial College London London W2 1PG U.K.;

    State Key Joint Laboratory for Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and Health Peking University Beijing 100871 P. R. China;

    State Key Joint Laboratory for Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and Health Peking University Beijing 100871 P. R. China;

    State Key Joint Laboratory for Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and Health Peking University Beijing 100871 P. R. China;

    State Key Joint Laboratory for Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and Health Peking University Beijing 100871 P. R. China;

    State Key Joint Laboratory for Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and Health Peking University Beijing 100871 P. R. China;

    State Key Joint Laboratory for Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and Health Peking University Beijing 100871 P. R. China;

    State Key Joint Laboratory for Environmental Simulation and Pollution Control College of EnvironmentalSciences and Engineering and Center for Environment and Health Peking University Beijing 100871 P. R. China;

    State Key Joint Laboratory for Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and Health Peking University Beijing 100871 P. R. China;

    Peking University Hospital Peking University Beijing 100871 P. R. China;

    State Key Joint Laboratory for Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and Health Peking University Beijing 100871 P. R. China;

    State Key Joint Laboratory for Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering and Center for Environment and Health Peking University Beijing 100871 P. R China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    exposotnics; fine particulate matter (PM_(2.5) ); inflammation; metabolic disorder; organic components; personal exposure;

    机译：exposotnics;细颗粒物质（PM_（2.5））;炎;代谢紊乱;有机成分;个人曝光;

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