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首页> 外文期刊>Environmental Science & Technology >Environmental Selenium Research: From Microscopic Processes to Global Understanding
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Environmental Selenium Research: From Microscopic Processes to Global Understanding

机译：环境硒研究：从微观过程到全球理解

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摘要

The essential trace element selenium (Se) plays a fundamental role in human health. It is a component of several major metabolic pathways including thyroid hormone metabolism, antioxidant defense systems, and immune function.In humans, selenium has one of the narrowest ranges between dietary deficiency (<40 μg per day) and toxic levels (>400 μg per day).~2 International agencies have therefore set dietary reference values in the range of 30-55 μg per day for Se intake.~3 Insufficient Se supply has been associated with growth retardation and impaired bone metabolism~4 and is thought to cause abnormalities in thyroid function.~5 In central China and South East Siberia, very low Se contents of locally produced food have been related to geographically widespread endemic diseases, such as Keshan disease (a cardiomyiopathy) that was first recognized to be related to Se deficiency in 1935, or the chronic, degenerative osteoarthrosis Kashin Beck disease. Daily intake in affected areas ranges from only ~7 to 11 μg per person per day/ On a global scale it is estimated that 0.5-1 billion people are directly affected by Se deficiency.~8 In general, areas low in natural Se are more widespread and extensive than areas with excess levels of Se.
机译：必需的微量元素硒（Se）在人类健康中起着重要作用。它是甲状腺激素代谢，抗氧化防御系统和免疫功能等几种主要代谢途径的组成部分。在人类中，硒是饮食不足（每天<40μg）和毒性水平（>400μg/天）之间最窄的范围之一。 〜2国际机构因此将硒的摄入量设定为每天30-55μg的饮食参考值。〜3硒供应不足与生长发育迟缓和骨骼代谢受损有关〜4，被认为会导致异常〜5在中国中部和东南西伯利亚，当地生产的食物中硒含量极低与地理上广泛的地方病有关，例如克山病（一种心肌病），该病最初被认为与硒缺乏有关。 1935年，即慢性退化性骨关节炎Kashin Beck病。受影响地区的每日摄入量仅为每人每天约7至11微克/全球范围内，估计有0.5-1亿人直接受到硒缺乏的影响。〜8一般来说，天然硒含量低的地区更多硒含量高的地区分布广泛。

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  • 来源
    《Environmental Science & Technology》 |2012年第2期|p.571-579|共9页
  • 作者

    Lenny H. E. Winkel; C. Annette Johnson; Markus Lenz; Tim Grundl; Olivier X. Leupin; Manouchehr Amini; Laurent Charlet;

  • 作者单位

    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Ueberlandstrasse 133, P.O. Box 611, 8600 Duebendorf, Switzerland,Institute of Biogeochemistry and Pollutant Dynamics, Department of Environmental Sciences, Swiss Federal Institute of Technology(ETH) Zurich, 8092 Zurich, Switzerland;

    rnEawag, Swiss Federal Institute of Aquatic Science and Technology, Ueberlandstrasse 133, P.O. Box 611, 8600 Duebendorf, Switzerland;

    rnUniversity of Applied Sciences and Arts, Northwestern Switzerland (FHNW), Institute for Ecopreneurship, School of Life Sciences,Gruendenstrasse 40, 4132 Muttenz, Switzerland,Sub-Department of Environmental Technology, Wageningen University, 6700 EV Wageningen, The Netherlands;

    rnSchool of Freshwater Sciences and Department of Geosciences, University of Wisconsin-Milwaukee, 3209 North Maryland Avenue, Milwaukee, Wisconsin, United States;

    rnNagra, Hardstrasse 73, 5430 Wettingen, Switzerland;

    rnEawag, Swiss Federal Institute of Aquatic Science and Technology, Ueberlandstrasse 133, P.O. Box 611, 8600 Duebendorf, Switzerland;

    rnISTerre, Institute of Earth Sciences, University of Grenoble, CNRS, P.O. Box 53, 38041 Grenoble Cedex 9, France;

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