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首页> 外文期刊>Environmental Science & Technology >In Vivo Validation of the Unified BARGE Method to Assess the Bioaccessibility of Arsenic,Antimony,Cadmium,and Lead in Soils
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In Vivo Validation of the Unified BARGE Method to Assess the Bioaccessibility of Arsenic,Antimony,Cadmium,and Lead in Soils

机译：评估土壤中砷，锑，镉和铅的生物可及性的统一BARGE方法的体内验证

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摘要

The relative bioavailability of arsenic,antimony,cadmium,and lead for the ingestion pathway was measured in 16 soils contaminated by either smelting or mining activities using a juvenile swine model. The soils contained IS to 25 000 mg kg~(-1) As,18 to 60000 mg kg~(-1) Sb,20 to 184 mg kg~(-1) Cd,and 1460 to 40 214 mg kg~(-1) Pb. The bioavailability in the soils was measured in kidney,liver,bone,and urine relative to soluble salts of the four elements. The variety of soil types,the total concentrations of the elements,and the range of bioavailabilities found were considered to be suitable for calibrating the in vitro Unified BARGE bioaccessibility method. The bioaccessibility test has been developed by the BioAccessibility Research Group of Europe (BARGE) and is known as the Unified BARGE Method (UBM). The study looked at four end points from the in vivo measurements and two compartments in the in vitro study ("stomach* and "stomach and intestine"). Using benchmark criteria for assessing the "fitness for purpose" of the UBM bioaccessibility data to act as an analogue for bioavailability in risk assessment,the study shows that the UBM met criteria on repeatability (median relative standard deviation value <10%) and the regression statistics (slope 0.8 to 1.2 and r-square > 0.6) for As,Cd,and Pb. The data suggest a small bias in the UBM relative bioaccessibility of As and Pb compared to the relative bioavailabiUty measurements of 3% and 5% respectively. Sb did not meet the criteria due to the small ranee of bioaccessibility values found in the samples.
机译：使用少年猪模型，在16种土壤中，砷，锑，镉和铅的相对生物利用度是通过冶炼或采矿活动污染的，测量了其摄入途径。土壤中的IS含量为25,000 mg kg〜（-1）As，18 to 60000 mg kg〜（-1）Sb，20 to 184 mg kg〜（-1）Cd和1460 to 40214 mg kg〜（- 1）铅相对于四种元素的可溶性盐而言，在肾脏，肝脏，骨骼和尿液中测量了土壤中的生物利用度。各种土壤类型，元素的总浓度以及生物利用度的范围都被认为适合于校准体外统一BARGE生物利用度方法。生物可及性测试是由欧洲生物可及性研究小组（BARGE）开发的，被称为统一驳回法（UBM）。该研究从体内研究中的四个终点以及体外研究中的两个隔间（“胃*”和“肠胃”）中使用基准标准来评估UBM生物可及性数据的“适用性”作为风险评估中生物利用度的类似物，该研究表明，UBM符合As，Cd，As，数据表明，砷和铅的UBM相对生物利用度的偏差较小，分别为3％和5％，相对而言，锑的标准不大，因为样品中的生物利用度值很小。

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  • 来源
    《Environmental Science & Technology》 |2012年第11期|p.6252-6260|共9页
  • 作者

    Sebastien Denys; Julien Caboche; Karine Tack; Guido Rychen; Joanna Wragg; Mark Cave; Catherine Jondreville; Cyril Feidt;

  • 作者单位

    INERIS,Pare Technologique ALATA,BP 2,60 550 Verneuil-en-Halatte,France;

    URAFPA,Unite de Recherche Animal et Fonctionnalites des Produits Animaux,Nancy Universite,INRA,2 avenue de la Foret de Haye BP172,5450S Vandceuvre-les-Nancy,France,INERIS,Pare Technologique ALATA,BP 2,60 550 Verneuil-en-Halatte,France;

    INERIS,Pare Technologique ALATA,BP 2,60 550 Verneuil-en-Halatte,France;

    URAFPA,Unite de Recherche Animal et Fonctionnalites des Produits Animaux,Nancy Universite,INRA,2 avenue de la Foret de Haye BP172,5450S Vandceuvre-les-Nancy,France;

    British Geological Survey,Keyworth,Nottingham,United Kingdom,NG12 5GG;

    British Geological Survey,Keyworth,Nottingham,United Kingdom,NG12 5GG;

    URAFPA,Unite de Recherche Animal et Fonctionnalites des Produits Animaux,Nancy Universite,INRA,2 avenue de la Foret de Haye BP172,5450S Vandceuvre-les-Nancy,France;

    URAFPA,Unite de Recherche Animal et Fonctionnalites des Produits Animaux,Nancy Universite,INRA,2 avenue de la Foret de Haye BP172,5450S Vandceuvre-les-Nancy,France;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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