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首页> 外文期刊>Environmental Science & Technology >Factors Associated with Serum Polybrominated Diphenyl Ether (PBDE) Levels Among School-Age Children in the CHAMACOS Cohort
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Factors Associated with Serum Polybrominated Diphenyl Ether (PBDE) Levels Among School-Age Children in the CHAMACOS Cohort

机译：CHAMACOS队列中学龄儿童血清多溴联苯醚（PBDE）水平相关因素

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摘要

Polybrominated diphenyl ethers (PBDEs) are a class of flame retardants historically used in textiles, furniture, and electronic products. Recent studies have documented widespread PBDE exposure to humans, with higher levels measured in children than adults. We analyzed 10 tri- to hepta- BDE congener levels in blood collected from 7-year old Mexican-American children living in an agriculture community in California (n = 272). The most frequently detected PBDE congeners in child serum were BDE-47, -99, -100, and -153, all of which were measured in >99% of the children. We used multiple linear regression models to examine associations between child total PBDE levels (ng/g lipid) and determinants of exposure. Factors positively associated with higher PBDE levels in the children were total PBDE levels in maternal serum during pregnancy, duration of exclusive breastfeeding, and having no safe places to play in their neighborhood. Child BMI was inversely associated with serum PBDE levels (regression p-values <0.05). Our findings confirm that exposure to the penta-BDE mixture is ongoing, and that Mexican-American children living in California may be experiencing higher PBDE exposure from their environment compared to children sampled from the general U.S. population. Additional research is needed to assess the health impacts of these exposures.
机译：多溴二苯醚（PBDEs）是一类历史上用于纺织品，家具和电子产品的阻燃剂。最近的研究表明，多溴二苯醚广泛暴露于人类，在儿童中测得的水平高于成年人。我们分析了从生活在加利福尼亚州一个农业社区（n = 272）的7岁墨西哥裔美国儿童采集的血液中10种三溴到七溴二苯醚同源物的水平。儿童血清中最常检测到的PBDE同源物是BDE-47，-99，-100和-153，所有这些都在99％以上的儿童中进行了测量。我们使用了多个线性回归模型来检验儿童总PBDE水平（ng / g脂质）与接触决定因素之间的关联。与儿童中较高的PBDE水平呈正相关的因素是孕期孕妇血清中的PBDE总水平，纯母乳喂养的时间以及在附近没有安全的场所玩耍。儿童BMI与血清PBDE水平呈负相关（回归p值<0.05）。我们的研究结果证实了五溴二苯醚混合物的暴露仍在继续，居住在加利福尼亚的墨西哥裔美国儿童与环境中的PBDE暴露相比可能比美国普通人群的儿童更高。需要更多的研究来评估这些暴露对健康的影响。

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  • 来源
    《Environmental Science & Technology》 |2012年第13期|p.7373-7381|共9页
  • 作者

    Asa Bradman; Rosemary Castorina; Andreas Sjoedin; Laura Fenster; Richard S. Jones; Kim G. Harley; Jonathan Chevrier; Nina T. Holland; Brenda Eskenazi;

  • 作者单位

    Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley,California, United States;

    Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley,California, United States;

    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE Mail Stop F-17, Atlanta, Georgia, United States;

    Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley,California, United States;

    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE Mail Stop F-17, Atlanta, Georgia, United States;

    Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley,California, United States;

    Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley,California, United States;

    Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley,California, United States;

    Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley,California, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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