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首页> 外文期刊>Environmental Science & Technology >Organic Selenium Supplementation Increases Mercury Excretion and Decreases Oxidative Damage in Long-Term Mercury-Exposed Residents from Wanshan, China
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Organic Selenium Supplementation Increases Mercury Excretion and Decreases Oxidative Damage in Long-Term Mercury-Exposed Residents from Wanshan, China

机译:补充有机硒增加了来自中国万山的长期汞暴露居民中的汞排泄并减少了氧化损伤

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摘要

Due to a long history of extensive mercury mining and smelting activities, local residents in Wanshan, China, are suffering from elevated mercury exposure. The objective of the present study was to study the effects of oral supplementation with selenium-enriched yeast in these long-term mercury-exposed populations. One hundred and three volunteers from Wanshan area were recruited and 53 of them were supplemented with 100 μg of organic selenium daily as selenium-enriched yeast while 50 of them were supplemented with the nonselenium-enriched yeast for 3 months. The effects of selenium supplementation on urinary mercury, selenium, and oxidative stress-related biomarkers including malondialdehyde and 8-hydroxy-2-deoxyguanosine were assessed. This 3-month selenium supplementation trial indicated that organic selenium supplementation could increase mercury excretion and decrease urinary malondialdehyde and 8-hydroxy-2-deoxyguanosine levels in local residents.
机译:由于广泛的汞开采和冶炼活动历史悠久,中国万山的当地居民遭受的汞暴露增加。本研究的目的是研究口服富硒酵母对这些长期暴露于汞的人群的影响。招募了来自万山区的103名志愿者,其中53名每天补充100μg的有机硒作为富硒酵母,而其中50名则补充了3个月的非硒酵母。评估了硒对尿中汞,硒和与氧化应激相关的生物标志物(包括丙二醛和8-羟基-2-脱氧鸟苷)的影响。这项为期3个月的硒补充试验表明,补充有机硒可以增加汞的排泄并降低当地居民的尿中丙二醛和8-羟基-2-脱氧鸟苷水平。

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  • 来源
    《Environmental Science & Technology》 |2012年第20期|p.11313-11318|共6页
  • 作者单位

    Multidiscipline Initiative Center and CAS Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China;

    Guizhou Institute of Environmental Science and Designing, Guiyang 550002, China;

    National Center for Nanoscience and Technology, Beijing 100190, China;

    Multidiscipline Initiative Center and CAS Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China;

    Multidiscipline Initiative Center and CAS Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China;

    Guizhou Institute of Environmental Science and Designing, Guiyang 550002, China;

    The Third Hospital of Peking University, Beijing 100191, China;

    Uppsala University, Uppsala SE-751 05, Sweden;

    Multidiscipline Initiative Center and CAS Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China;

    Multidiscipline Initiative Center and CAS Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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