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首页> 外文期刊>Environmental Science & Technology >Exceptionally High Serum Concentrations of Perfluorohexanesulfonate in a Canadian Family are Linked to Home Carpet Treatment Applications
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Exceptionally High Serum Concentrations of Perfluorohexanesulfonate in a Canadian Family are Linked to Home Carpet Treatment Applications

机译：加拿大家庭中全氟己烷磺酸盐的超高浓度与家庭地毯处理应用有关

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摘要

Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are normally the dominant perfluoroalkyl substances (PFASs) in human serum, but here a Canadian family of seven was identified with particularly high exposure to perfluorohexanesulfonate (PFHxS). Disproportionately high serum PFHxS concentrations (range 27.5-423 ng/mL) and moderately high PFOS (range 15.2-108 ng/mL) and PFOA (range 2.40-9.23 ng/mL) concentrations were detected in the family members, with all three chemicals being highest in the youngest children. We therefore sought to identify the source(s) and pathway(s) of this unusual exposure, and to study the excretion of PFASs for this family. Serum, urine, and stool were sampled from family members, carpet, dust, and air were sampled in the home, and a questionnaire was administered. Over 15 years, the family's household carpets were treated 8 times with Scotchgard formulations. Elevated concentrations of PFHxS were detected in household dust (2780 ng/g dust) and in family room carpet (2880 ng/g carpet), and the primary mode of excretion for the major PFASs was through urine. The high PFHxS and moderately high PFOS concentrations in serum and household samples are consistent with the known PFAS content of certain Scotchgard formulations, and exposure was likely through dust ingestion and/or inhalation.
机译：全氟辛烷磺酸盐（PFOS）和全氟辛酸盐（PFOA）通常是人血清中占主导地位的全氟烷基物质（PFASs），但是在这里，加拿大一个7口之家被确定与全氟己烷磺酸盐（PFHxS）的接触特别高。在所有三种化学物质的家庭成员中，均检测到血清PFHxS浓度过高（范围27.5-423 ng / mL）和中等偏高的PFOS（范围15.2-108 ng / mL）和PFOA（范围2.40-9.23 ng / mL）。在最小的孩子中最高。因此，我们试图确定这种异常暴露的来源和途径，并研究该家庭的PFAS排泄。从家庭成员中抽取血清，尿液和粪便，在家中抽取地毯，灰尘和空气，并进行问卷调查。在15年的时间里，该家族的家用地毯用Scotchgard配方处理了8次。在家庭灰尘（2780 ng / g灰尘）和家庭房间地毯（2880 ng / g地毯）中检测到PFHxS的浓度升高，主要PFAS的主要排泄方式是通过尿液。血清和家庭样品中的高PFHxS和中等高的PFOS浓度与某些苏格兰配方中已知的PFAS含量一致，并且可能通过粉尘的摄入和/或吸入而暴露。

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  • 来源
    《Environmental Science & Technology》 |2012年第23期|12960-12967|共8页
  • 作者

    Sanjay Beesoon; Stephen J. Genuis; Jonathan P. Benskin; Jonathan W. Martin;

  • 作者单位

    Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada;

    Department of Medicine, University of Alberta, Edmonton, AB, Canada;

    Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada,Department of Medicine, University of Alberta, Edmonton, AB, Canada;

    Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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