...
首页> 外文期刊>Environmental Science & Technology >Pyrethroid Pesticide Exposure and Risk of Childhood Acute Lymphocytic Leukemia in Shanghai
【24h】

Pyrethroid Pesticide Exposure and Risk of Childhood Acute Lymphocytic Leukemia in Shanghai

机译:拟除虫菊酯类农药的暴露与上海儿童急性淋巴细胞白血病的风险

获取原文
获取原文并翻译 | 示例
           

摘要

Significant amounts of pyrethroid pesticides are used throughout China. Previous studies have suggested that exposure to pesticides may increase the risk of childhood cancer; however, few studies have focused on pyrethroid metabolites. We investigated five nonspecific metabolites of pyrethroid pesticides found in children's urine and examined the correlation with childhood leukemia. We conducted a hospital-based case-control study of childhood acute lymphocytic leukemia (ALL) in Shanghai between 2010 and 2011. The study included 176 children aged 0-14 years and 180 controls matched for age and sex. Compared with those in the lowest quartiles of total and individual metabolites, the highest quartiles were associated with an approximate 2- fold increased risk of ALL [total metabolites: odds ratio (OR) = 2.75, 95% confidence interval (CI), 1.43-5.29; cis-DCCA: OR = 2.21, 95% CI, 1.16-4.19; rrans-DCCA: OR = 2.33, 95% CI, 1.23-4.41; and 3-PBA: OR = 1.84, 95% CI, 1.00-3.38], and most of the positive trends were significant (p < 0.05). Our findings suggest that urinary levels of pyrethroid metabolites may be associated with an elevated risk of childhood ALL and represent a previously unreported quantitative exposure assessment for childhood leukemia.
机译:整个中国使用大量的拟除虫菊酯农药。先前的研究表明,接触杀虫剂可能会增加儿童患癌症的风险。然而,很少有研究关注拟除虫菊酯的代谢产物。我们调查了在儿童尿液中发现的5种拟除虫菊酯农药的非特异性代谢物,并研究了其与儿童白血病的相关性。我们于2010年至2011年在上海进行了一项基于医院的儿童急性淋巴细胞白血病(ALL)病例对照研究。该研究包括176名0-14岁的儿童和180名年龄和性别相匹配的对照。与总代谢物和单个代谢物的最低四分位数相比,最高四分位数与ALL的风险增加约2倍[总代谢物:优势比(OR)= 2.75,95%置信区间(CI),1.43 5.29;顺式DCCA:OR = 2.21,95%CI,1.16-4.19; rrans-DCCA:OR = 2.33,95%CI,1.23-4.41;和3-PBA:OR = 1.84,95%CI,1.00-3.38],大多数阳性趋势均显着(p <0.05)。我们的发现表明,拟除虫菊酯代谢物的尿液水平可能与儿童ALL的风险升高有关,代表了以前未报道的儿童白血病定量暴露评估。

著录项

  • 来源
    《Environmental Science & Technology》 |2012年第24期|13480-13487|共8页
  • 作者单位

    MOE and Shanghai Key Laboratory of Children's Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China,These authors contributed equally to this work;

    Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China,These authors contributed equally to this work;

    Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China;

    Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China;

    Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan;

    Environmental Health Department, Nagoya City Public Health Research Institute, Nagoya, Japan;

    Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China;

    Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China;

    Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China,MOE and Shanghai Key Laboratory of Children's Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号