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首页> 外文期刊>Environmental Science & Technology >Predicting Hormetic Effects of lonic Liquid Mixtures on Luciferase Activity Using the Concentration Addition Model
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Predicting Hormetic Effects of lonic Liquid Mixtures on Luciferase Activity Using the Concentration Addition Model

机译：使用浓度加成模型预测离子液体混合物对萤光素酶活性的钟乳效应

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摘要

The concept of hormesis has generated considerable interest within the environmental and toxicological communities over the past decades. However, toxicological evaluation and prediction of hormesis in mixtures are challenging and only just unfolding. The hormetic effects often ionic liquids (ILs), singly and in mixtures in the ratios of their individual EC_(50), EC_(10), EC_0, and EC_m (maximal stimulatory effect concentration), on luciferase luminescence were determined by using microplate toxicity analysis. There was good agreement between the effects observed and predicted by concentration addition (CA) for all four mixtures. This evidence supports the use of CA model as a default approach for assessing the combined effect of chemicals at the molecular level. Focusing on the selected points of the concentration-response curves (CRCs) of mixtures, the mixtures of IL chemicals mixed at concentrations that individually showed stimulatory effects could produce inhibitory or no effects, and the mixture of IL chemicals mixed at concentrations that individually showed no effects could produce significant inhibitory effect. The three interesting phenomena in mixture hormesis may have important implications for current risk assessment practices.
机译：在过去的几十年中，毒副作用的概念引起了环境和毒理学界的极大关注。然而，混合物的毒理学评估和毒力预测是具有挑战性的，并且仅在进行中。通过使用微孔板毒性测定了离子液体（ILs）对萤光素酶发光的单独或混合的致幻作用，通常以其各自的EC_（50），EC_（10），EC_0和EC_m（最大刺激作用浓度）的比例进行。分析。对于所有四种混合物，观察到的效果和通过浓度添加（CA）预测的效果之间都有很好的一致性。该证据支持使用CA模型作为评估化学物质在分子水平上的综合作用的默认方法。着眼于混合物的浓度-响应曲线（CRC）的选定点，以单独显示出刺激作用的浓度混合的IL化学品混合物可能会产生抑制作用或没有作用，而以单独显示出浓度的IL化学物质的混合物不会产生抑制作用。作用可能产生明显的抑制作用。混合兴奋剂中的三个有趣现象可能会对当前的风险评估实践产生重要影响。

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  • 来源
    《Environmental Science & Technology》 |2011年第4期|p.1623-1629|共7页
  • 作者

    Hui-Lin Ge; Shu-Shen Liu; Xiang-Wei Zhu; Hai-Ling Liu; Li-Juan Wang;

  • 作者单位

    Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering,Tongji University, Shanghai 200092, China;

    Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering,Tongji University, Shanghai 200092, China,State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering,Tongji University, Shanghai 200092, China;

    Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering,Tongji University, Shanghai 200092, China;

    State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering,Tongji University, Shanghai 200092, China;

    Key Laboratory of Yangtze River Water Environment, Ministry of Education, College of Environmental Science and Engineering,Tongji University, Shanghai 200092, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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