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首页> 外文期刊>Environmental Science & Technology >Investigation of Human Exposure to Triclocarban after Showering and Preliminary Evaluation of Its Biological Effects
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Investigation of Human Exposure to Triclocarban after Showering and Preliminary Evaluation of Its Biological Effects

机译：淋浴后人体接触三氯卡班的调查及其生物学效应的初步评估

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摘要

The antibacterial soap additive triclocarban (TCC) is widely used in personal care products. TCC has a high environmental persistence. We developed and validated a sensitive online solid-phase extraction-LC-MS/MS method to rapidly analyze TCC and its major metabolites in urine and other biological samples to assess human exposure. We measured human urine concentrations 0-72 h after showering with a commercial bar soap containing 0.6% TCC. The major route of renal elimination was excretion as N-glucuronides. The absorption was estimated at 0.6% of the 70 ± 15 mg of TCC in the soap used. The TCC-N-glucuronide urine concentration varied widely among the subjects, and continuous daily use of the soap led to steady state levels of excretion. In order to assess potential biological effects arising from this exposure, we screened TCC for the inhibition of human enzymes in vitro. We demonstrate that TCC is a potent inhibitor of the enzyme soluble epoxide hydrolase (sEH), whereas TCC's major metabolites lack strong inhibitory activity. Topical administration of TCC at similar levels to rats in a preliminary in vivo study, however, failed to alter plasma biomarkers of sEH activity. Overall the analytical strategy described here revealed that use of TCC soap causes exposure levels that warrant further evaluation.
机译：抗菌肥皂添加剂三氯卡班（TCC）被广泛用于个人护理产品中。 TCC具有很高的环境持久性。我们开发并验证了一种灵敏的在线固相萃取-LC-MS / MS方法，可快速分析尿液和其他生物样品中的TCC及其主要代谢产物，以评估人体暴露水平。我们在用含有0.6％TCC的商业香皂淋浴后测量了0-72小时的人类尿液浓度。肾脏消除的主要途径是排泄为N-葡萄糖醛酸。据估计，所用肥皂中的TCC为70±15毫克，吸收率为0.6％。在受试者之间，TCC-N-葡萄糖醛酸尿液浓度变化很大，每天持续使用肥皂会导致稳态排泄水平。为了评估这种暴露引起的潜在生物学效应，我们筛选了TCC在体外对人酶的抑制作用。我们证明，TCC是一种有效的酶可溶性环氧化物水解酶（sEH）抑制剂，而TCC的主要代谢产物缺乏强大的抑制活性。在一项初步的体内研究中，以与大鼠相似的水平局部施用TCC，未能改变sEH活性的血浆生物标志物。总体而言，此处描述的分析策略表明，使用TCC肥皂会导致暴露水平值得进一步评估。

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  • 来源
    《Environmental Science & Technology》 |2011年第7期|p.3109-3115|共7页
  • 作者

    Nils Helge Schebb; Bora Inceoglu; Ki Chang Ahn; Christophe Morisseau; Shirley J. Gee; Bruce D. Hammock;

  • 作者单位

    Department of Entomology and Cancer Center, University of California, Davis, One Shields Avenue, Davis, California 95616, United States;

    Department of Entomology and Cancer Center, University of California, Davis, One Shields Avenue, Davis, California 95616, United States;

    Department of Entomology and Cancer Center, University of California, Davis, One Shields Avenue, Davis, California 95616, United States;

    Department of Entomology and Cancer Center, University of California, Davis, One Shields Avenue, Davis, California 95616, United States;

    Department of Entomology and Cancer Center, University of California, Davis, One Shields Avenue, Davis, California 95616, United States;

    Department of Entomology and Cancer Center, University of California, Davis, One Shields Avenue, Davis, California 95616, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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