...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Environmental Science & Technology >Assessing the Quantitative Relationships between Preschool Children's Exposures to Bisphenol A by Route and Urinary Biomonitoring
【24h】

Assessing the Quantitative Relationships between Preschool Children's Exposures to Bisphenol A by Route and Urinary Biomonitoring

机译：评估学龄前儿童通过路线接触双酚A与尿液生物监测之间的定量关系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Limited published information exists on young children's exposures to bisphenol A (BPA) in the United States using urinary biomonitoring. In a previous project, we quantified the aggregate exposures of 257 preschool children to BPA in environmental and personal media over 48-h periods in 2000-2001 at homes and daycares in North Carolina and Ohio. In the present study for 81 Ohio preschool children ages 23-64 months, we quantified the children's urinary total BPA (free and conjugated) concentrations over these same 48-h periods in 2001. Then, we examined the quantitative relationships between the children's intakes doses of BPA through the dietary ingestion, nondietary ingestion, and inhalation routes and their excreted amounts of urinary BPA. BPA was detected in 100% of the urine samples. The estimated median intake doses of BPA for these 81 children were 109 ng/ kg/day (dietary ingestion), 0.06 ng/kg/day (nondietary ingestion), and 0.27 ng/kg/day (inhalation); their estimated median excreted amount of urinary BPA was 114 ng/kg/day. Our multivariable regression model showed that dietary intake of BPA (p = 0.04) and creatinine concentration (p = 0.004) were significant predictors of urinary BPA excretion, collectively explaining 1796 of the variability in excretion. Dietary ingestion of BPA accounted for >9S% of the children's excreted amounts of urinary BPA
机译：在美国，使用尿液生物监测技术对幼儿接触双酚A（BPA）的信息存在公开的信息有限。在先前的项目中，我们对2000-2001年在北卡罗来纳州和俄亥俄州的家庭和日托机构中48小时内环境和个人媒体中257名学龄前儿童在BPA中的总暴露进行了量化。在本项针对81名年龄在23-64个月的俄亥俄州学龄前儿童的研究中，我们对2001年在相同的48小时内儿童的尿液中总BPA（游离和结合）浓度进行了定量。然后，我们研究了儿童摄入剂量之间的定量关系通过饮食摄入，非饮食摄入和吸入途径摄入双酚A，以及尿中双酚A的排泄量。在100％的尿液样本中检测到BPA。这81名儿童的BPA估计中位摄入剂量为109 ng / kg /天（饮食），0.06 ng / kg /天（非饮食）和0.27 ng / kg /天（吸入）；他们估计的尿液BPA排泄量中位数为114 ng / kg /天。我们的多变量回归模型显示，饮食中BPA的摄入量（p = 0.04）和肌酐浓度（p = 0.004）是尿液BPA排泄的重要预测因子，共同解释了1796年的排泄变异性。饮食中摄入的双酚A占儿童尿液双酚A排泄量的> 9S％

著录项

  • 来源
    《Environmental Science & Technology》 |2011年第12期|p.5309-5316|共8页
  • 作者

    Marsha K. Morgan; Paul A. Jones; Antonia M Calafat; Xiaoyun Ye; Carry W. Croghan; Jane C. Chuang; Nancy K. Wilson; Matthew S. Clifton; Zaida Figueroa; Linda S. Sheldon;

  • 作者单位

    National Exposure Research Laboratory, USEPA, Research Triangle Park, North Carolina 27713, United States;

    National Exposure Research Laboratory, USEPA, Research Triangle Park, North Carolina 27713, United States;

    Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States;

    Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States;

    National Exposure Research Laboratory, USEPA, Research Triangle Park, North Carolina 27713, United States;

    Battefle, Columbus, Ohio 43201, United States;

    Battelle, Durham, North Carolina 27713, United States;

    National Exposure Research Laboratory, USEPA, Research Triangle Park, North Carolina 27713, United States;

    Office of Pesticide Programs, USEPA, Washington, D.C. 20460, United States;

    National Exposure Research Laboratory, USEPA, Research Triangle Park, North Carolina 27713, United States;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号