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Enantiomer Fractions of Chiral Perfluorooctanesulfonate (PFOS) in Human Sera

机译：人血清中手性全氟辛烷磺酸（PFOS）的对映体部分

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摘要

Perfluorooctane sulfonate (PFOS) is the most prominent perfluoroalkyl contaminant in humans and wildlife, but there is great uncertainty in exposure pathways, particularly with respect to the importance of PFOS-precursors (PreFOS). We explored the hypothesis that nonracemic proportions of chiral PFOS in serum are qualitative and semiquantitative biomarkers of human PreFOS exposure. A new chiral HPLC-MS/MS method was developed for alpha-perfiuoromethvl branched PFOS (lm-PFOS, typically 2-3% of total PFOS) and applied to enantiomer fraction (EF) analysis in biological samples. In blood and tissues of rodents exposed subchronically to electrochemical PFOS, lm-PFOS was racemic(EF = 0.485-0.511) and no evidence for enanboselective excretion was found in this model mammal lm-PFOS in serum of pregnant women, from Edmonton, was significantly nonracemic, with a mean EF (±standard deviation) of 0.432 ± 0.009, similar to pooled Norm American serum. In a highly exposed Edmonton family (mother, father, and S children) living in a house where ScotchGard had been applied repeatedly to carpet and upholstery, EFs ranged from 0.35 to 0.43, significantly more nonracemic man in pregnant women. Semiquantitative estimates of % serum 1 m-PFOS coming from lm-PreFOS biotransformation in both subpopulations were in reasonable agreement with model predictions of human exposure to PFOS from PreFOS. The data were overall suggestive that the measured nonracemic EFs were influenced by the relative extent of exposure to PreFOS. The possibility of using lm-PFOS EFs for assessing the relative contribution of lm-PreFOS (or PreFOS in general) in biological samples requires farmer application before being fully validated, but could be a powerful tool for probing general sources of PFOS in environments where the importance of PreFOS is unknown.
机译：全氟辛烷磺酸盐（PFOS）是人类和野生生物中最主要的全氟烷基污染物，但是暴露途径存在很大不确定性，尤其是在PFOS前体（PreFOS）的重要性方面。我们探索了以下假设：血清中手性PFOS的非外消旋比例是人类PreFOS暴露的定性和半定量生物标记。已开发出一种新的手性HPLC-MS / MS方法用于α-全氟甲基支链PFOS（lm-PFOS，通常占总PFOS的2-3％），并用于生物样品中的对映体组分（EF）分析。在长期暴露于电化学全氟辛烷磺酸的啮齿动物的血液和组织中，lm-PFOS具有消旋性（EF = 0.485-0.511），并且在该模型哺乳动物的哺乳动物血清中，从埃德蒙顿的孕妇血清中未发现排泄选择性排泄的证据显着。非消旋的，平均EF（±标准偏差）为0.432±0.009，与标准Norm American血清相似。在埃德蒙顿一家高暴露的家庭（母亲，父亲和S个孩子）居住的房屋中，ScotchGard被反复应用于地毯和室内装潢中，EF的范围从0.35到0.43，在孕妇中非外向型男人的比例明显更高。来自两个亚群中lm-PreFOS生物转化的血清1 m-PFOS百分含量的半定量估计与人类从PreFOS暴露于PFOS的模型预测模型合理地吻合。数据总体表明，所测的非消旋EFs受PreFOS相对暴露程度的影响。使用lm-PFOS EF评估生物样品中lm-PreFOS（或一般说是PreFOS）的相对贡献的可能性需要在完全验证之前向农民应用，但对于在以下环境中探测PFOS的一般来源而言，它可能是一个强大的工具。 PreFOS的重要性未知。

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  • 来源
    《Environmental Science & Technology》 |2011年第20期|p.8907-8914|共8页
  • 作者

    Yuan Wang; Sanjay Beesoon; Jonathan P. Benskin; Amila O. De Silva; Stephen J. Genuis; Jonathan W. Martin;

  • 作者单位

    Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta,Edmonton, Alberta, Canada, T6G 2G3;

    Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta,Edmonton, Alberta, Canada, T6G 2G3;

    Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta,Edmonton, Alberta, Canada, T6G 2G3;

    Aquatic Ecosystem Protection Research Division, Water Science and Technology Directorate, Environment Canada, 867 Lakeshore Road, Burlington, Ontario, Canada, L7R4A6;

    Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada, T6G 2R7;

    Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, University of Alberta,Edmonton, Alberta, Canada, T6G 2G3;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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