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Toxicity of Ingested Cadmium to the Nematode Caenorhabditis elegans

机译:摄入的镉对线虫秀丽隐杆线虫的毒性

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摘要

Benthic organisms ingest dissolved and particle-bound contaminants together with their food, whereas it is not clear which fraction of the ingested suspension causes the toxic effects. In the standard toxicity test using the nematode Caenorhabditis elegans, the organisms are fed with bacteria that bind contaminants, thus influencing the bioavailabuity of the contaminants for the organisms. To unravel the role of food bacteria in the toxicity of contaminants in C elegans, suspensions with varying densities of bacteria were spiked with the toxic metal cadmium (Cd), either via the water or via the bacteria. The toxicity of Cd to C elegans was clearly related to the uptake of bacteria in the nematode's gut. An increase in the bacterial density resulted in a significant decrease in the toxicity of Cd such that toxic effects better correlated with the aqueous than with the bacterial-bound or total Cd concentrations. The results suggested that the aqueous Cd that was ingested together with the food was the best available fraction and thereby mainly caused the observed toxicity on the reproduction of C elegans.
机译:底栖生物与食物一起摄入溶解的和颗粒结合的污染物,但是尚不清楚摄入悬浮液的哪一部分会引起毒性作用。在使用线虫秀丽隐杆线虫进行的标准毒性测试中,向生物体喂食结合了污染物的细菌,从而影响了污染物对生物体的生物利用度。为了弄清食用细菌在线虫中污染物毒性中的作用,通过水或细菌,将有不同细菌密度的悬浮液掺入有毒金属镉(Cd)。镉对秀丽隐杆线虫的毒性显然与线虫肠道中细菌的摄取有关。细菌密度的增加导致Cd的毒性显着降低,因此与水结合的Cd浓度或与细菌结合的Cd或总Cd浓度相比,毒性作用与水溶液的相关性更好。结果表明,与食物一起摄入的Cd水溶液是最佳的可利用部分,因此主要导致观察到的对秀丽隐杆线虫繁殖的毒性。

著录项

  • 来源
    《Environmental Science & Technology》 |2011年第23期|p.10219-10225|共7页
  • 作者单位

    Ecossa, Giselastrasse 6, 82319 Starnberg, Germany;

    Department of Animal Ecology, University of Bielefeld, Morgenbreede 45, 33615 Bielefeld, Germany;

    Department of Animal Ecology, University of Bielefeld, Morgenbreede 45, 33615 Bielefeld, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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