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首页> 外文期刊>Environmental Science & Technology >Reply to 2nd Comment on 'Effects of Triclocarban, Triclosan, And Methyl Triclosan on Thyroid Hormone Action and Stress in Frog and Mammalian Culture Systems'
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Reply to 2nd Comment on 'Effects of Triclocarban, Triclosan, And Methyl Triclosan on Thyroid Hormone Action and Stress in Frog and Mammalian Culture Systems'

机译：对“三氯卡班，三氯生和甲基三氯生对青蛙和哺乳动物培养系统中甲状腺激素作用和应激的影响”的第二条评论的答复

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摘要

The letter to the editor by DeLeo et al. regarding our recent publication includes a number of misrepresentations that give the appearance of controversy over the findings. Both the cultured frog tail fin (C-fin) biopsy and the rodent GH3 cell assays were developed upon a solid scientific foundation dating back half a century. The C-fin assay is based upon Schaffer's discovery that cultured tadpole tails maintain their responsiveness to thyroid hormone (TH). Tail culture has been used by many laboratories and shows demonstrated utility as a screen for the identification of TH disruptors (for example, refs 3-5). The C-fin assay, first published in 2010, is a modification on this theme. The direct proliferative effect of THs on GH3 cells,8 developed in 1968, forms the basis of the T-screen published in 2005. GH3 cell-based assays have been employed to evaluate suspected TH disruptors by multiple laboratories with various modifications (for example, 11 and 12).
机译：DeLeo等人致编辑的信。关于我们最近的出版物，其中包括许多错误陈述，使人们对调查结果产生了争议。培养的蛙尾鳍活检和啮齿动物GH3细胞测定都是在半个世纪以来的坚实科学基础上发展起来的。 C鳍测定法基于Schaffer的发现，即培养的tail尾巴维持其对甲状腺激素（TH）的反应性。尾部培养已被许多实验室采用，并显示出可作为鉴定TH干扰物的筛选工具（例如，参考文献3-5）。 C-fin分析法于2010年首次发布，它是对此主题的修改。 THs对GH3细胞的直接增生作用[8]于1968年开发，构成了2005年发表的T型筛查的基础。基于GH3细胞的检测方法已被多个实验室进行了各种修改（例如， 11和12）。

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  • 来源
    《Environmental Science & Technology》 |2011年第23期|p.10285-10287|共3页
  • 作者

    Caren C. Helbing; Ashley Hinther; Jeremy E. Wulff; Caleb M. Bromba; Nik Veldhoen;

  • 作者单位

    Department of Biochemistry and Microbiology, University of Victoria, PO Box 3OSS Stn CSC, Victoria, B.C., Canada, V8W 3P6;

    Department of Biochemistry and Microbiology, University of Victoria, PO Box 3OSS Stn CSC, Victoria, B.C., Canada, V8W 3P6;

    Department of Chemistry, University of Victoria, PO Box 3065 Stn CSC, Victoria, B.C., Canada, V8W 3 V6;

    Department of Chemistry, University of Victoria, PO Box 3065 Stn CSC, Victoria, B.C., Canada, V8W 3 V6;

    Department of Biochemistry and Microbiology, University of Victoria, PO Box 3OSS Stn CSC, Victoria, B.C., Canada, V8W 3P6;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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